Optimization of critical parameters for coating of polymeric nanoparticles with plasma membrane vesicles by sonication

Top-down functionalization of nanoparticles with cellular membranes imparts nanoparticles with enhanced bio-interfacing capabilities. Initial methods for membrane coating involved physical co-extrusion of nanoparticles and membrane vesicles through a porous membrane; however, recent works employ son...

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Autores principales: Yang, Feipeng, Cabe, Maleen H., Ogle, Sean D., Sanchez, Veronica, Langert, Kelly A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671476/
https://www.ncbi.nlm.nih.gov/pubmed/34907240
http://dx.doi.org/10.1038/s41598-021-03422-5
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author Yang, Feipeng
Cabe, Maleen H.
Ogle, Sean D.
Sanchez, Veronica
Langert, Kelly A.
author_facet Yang, Feipeng
Cabe, Maleen H.
Ogle, Sean D.
Sanchez, Veronica
Langert, Kelly A.
author_sort Yang, Feipeng
collection PubMed
description Top-down functionalization of nanoparticles with cellular membranes imparts nanoparticles with enhanced bio-interfacing capabilities. Initial methods for membrane coating involved physical co-extrusion of nanoparticles and membrane vesicles through a porous membrane; however, recent works employ sonication as the disruptive force to reform membranes around the surface of nanoparticles. Although sonication is widely used, there remains a paucity of information on the effects of sonication variables on coating efficiency, leading to inconsistent membrane coating across studies. In this work, we present a systematic analysis of the sonication parameters that influence the membrane coating. The results showed that sonication amplitude, time, temperature, membrane ratio, sample volume, and density need to be considered in order to optimize membrane coating of polymeric nanoparticles.
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spelling pubmed-86714762021-12-16 Optimization of critical parameters for coating of polymeric nanoparticles with plasma membrane vesicles by sonication Yang, Feipeng Cabe, Maleen H. Ogle, Sean D. Sanchez, Veronica Langert, Kelly A. Sci Rep Article Top-down functionalization of nanoparticles with cellular membranes imparts nanoparticles with enhanced bio-interfacing capabilities. Initial methods for membrane coating involved physical co-extrusion of nanoparticles and membrane vesicles through a porous membrane; however, recent works employ sonication as the disruptive force to reform membranes around the surface of nanoparticles. Although sonication is widely used, there remains a paucity of information on the effects of sonication variables on coating efficiency, leading to inconsistent membrane coating across studies. In this work, we present a systematic analysis of the sonication parameters that influence the membrane coating. The results showed that sonication amplitude, time, temperature, membrane ratio, sample volume, and density need to be considered in order to optimize membrane coating of polymeric nanoparticles. Nature Publishing Group UK 2021-12-14 /pmc/articles/PMC8671476/ /pubmed/34907240 http://dx.doi.org/10.1038/s41598-021-03422-5 Text en © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Yang, Feipeng
Cabe, Maleen H.
Ogle, Sean D.
Sanchez, Veronica
Langert, Kelly A.
Optimization of critical parameters for coating of polymeric nanoparticles with plasma membrane vesicles by sonication
title Optimization of critical parameters for coating of polymeric nanoparticles with plasma membrane vesicles by sonication
title_full Optimization of critical parameters for coating of polymeric nanoparticles with plasma membrane vesicles by sonication
title_fullStr Optimization of critical parameters for coating of polymeric nanoparticles with plasma membrane vesicles by sonication
title_full_unstemmed Optimization of critical parameters for coating of polymeric nanoparticles with plasma membrane vesicles by sonication
title_short Optimization of critical parameters for coating of polymeric nanoparticles with plasma membrane vesicles by sonication
title_sort optimization of critical parameters for coating of polymeric nanoparticles with plasma membrane vesicles by sonication
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671476/
https://www.ncbi.nlm.nih.gov/pubmed/34907240
http://dx.doi.org/10.1038/s41598-021-03422-5
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