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A low-cost and shielding-free ultra-low-field brain MRI scanner

Magnetic resonance imaging is a key diagnostic tool in modern healthcare, yet it can be cost-prohibitive given the high installation, maintenance and operation costs of the machinery. There are approximately seven scanners per million inhabitants and over 90% are concentrated in high-income countrie...

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Autores principales: Liu, Yilong, Leong, Alex T. L., Zhao, Yujiao, Xiao, Linfang, Mak, Henry K. F., Tsang, Anderson Chun On, Lau, Gary K. K., Leung, Gilberto K. K., Wu, Ed X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671508/
https://www.ncbi.nlm.nih.gov/pubmed/34907181
http://dx.doi.org/10.1038/s41467-021-27317-1
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author Liu, Yilong
Leong, Alex T. L.
Zhao, Yujiao
Xiao, Linfang
Mak, Henry K. F.
Tsang, Anderson Chun On
Lau, Gary K. K.
Leung, Gilberto K. K.
Wu, Ed X.
author_facet Liu, Yilong
Leong, Alex T. L.
Zhao, Yujiao
Xiao, Linfang
Mak, Henry K. F.
Tsang, Anderson Chun On
Lau, Gary K. K.
Leung, Gilberto K. K.
Wu, Ed X.
author_sort Liu, Yilong
collection PubMed
description Magnetic resonance imaging is a key diagnostic tool in modern healthcare, yet it can be cost-prohibitive given the high installation, maintenance and operation costs of the machinery. There are approximately seven scanners per million inhabitants and over 90% are concentrated in high-income countries. We describe an ultra-low-field brain MRI scanner that operates using a standard AC power outlet and is low cost to build. Using a permanent 0.055 Tesla Samarium-cobalt magnet and deep learning for cancellation of electromagnetic interference, it requires neither magnetic nor radiofrequency shielding cages. The scanner is compact, mobile, and acoustically quiet during scanning. We implement four standard clinical neuroimaging protocols (T1- and T2-weighted, fluid-attenuated inversion recovery like, and diffusion-weighted imaging) on this system, and demonstrate preliminary feasibility in diagnosing brain tumor and stroke. Such technology has the potential to meet clinical needs at point of care or in low and middle income countries.
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spelling pubmed-86715082022-01-04 A low-cost and shielding-free ultra-low-field brain MRI scanner Liu, Yilong Leong, Alex T. L. Zhao, Yujiao Xiao, Linfang Mak, Henry K. F. Tsang, Anderson Chun On Lau, Gary K. K. Leung, Gilberto K. K. Wu, Ed X. Nat Commun Article Magnetic resonance imaging is a key diagnostic tool in modern healthcare, yet it can be cost-prohibitive given the high installation, maintenance and operation costs of the machinery. There are approximately seven scanners per million inhabitants and over 90% are concentrated in high-income countries. We describe an ultra-low-field brain MRI scanner that operates using a standard AC power outlet and is low cost to build. Using a permanent 0.055 Tesla Samarium-cobalt magnet and deep learning for cancellation of electromagnetic interference, it requires neither magnetic nor radiofrequency shielding cages. The scanner is compact, mobile, and acoustically quiet during scanning. We implement four standard clinical neuroimaging protocols (T1- and T2-weighted, fluid-attenuated inversion recovery like, and diffusion-weighted imaging) on this system, and demonstrate preliminary feasibility in diagnosing brain tumor and stroke. Such technology has the potential to meet clinical needs at point of care or in low and middle income countries. Nature Publishing Group UK 2021-12-14 /pmc/articles/PMC8671508/ /pubmed/34907181 http://dx.doi.org/10.1038/s41467-021-27317-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Liu, Yilong
Leong, Alex T. L.
Zhao, Yujiao
Xiao, Linfang
Mak, Henry K. F.
Tsang, Anderson Chun On
Lau, Gary K. K.
Leung, Gilberto K. K.
Wu, Ed X.
A low-cost and shielding-free ultra-low-field brain MRI scanner
title A low-cost and shielding-free ultra-low-field brain MRI scanner
title_full A low-cost and shielding-free ultra-low-field brain MRI scanner
title_fullStr A low-cost and shielding-free ultra-low-field brain MRI scanner
title_full_unstemmed A low-cost and shielding-free ultra-low-field brain MRI scanner
title_short A low-cost and shielding-free ultra-low-field brain MRI scanner
title_sort low-cost and shielding-free ultra-low-field brain mri scanner
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671508/
https://www.ncbi.nlm.nih.gov/pubmed/34907181
http://dx.doi.org/10.1038/s41467-021-27317-1
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