Depletion of central memory CD8(+) T cells might impede the antitumor therapeutic effect of Mogamulizumab

Regulatory T (Treg) cells are important negative regulators of immune homeostasis, but in cancers they tone down the anti-tumor immune response. They are distinguished by high expression levels of the chemokine receptor CCR4, hence their targeting by the anti-CCR4 monoclonal antibody mogamulizumab h...

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Detalles Bibliográficos
Autores principales: Maeda, Yuka, Wada, Hisashi, Sugiyama, Daisuke, Saito, Takuro, Irie, Takuma, Itahashi, Kota, Minoura, Kodai, Suzuki, Susumu, Kojima, Takashi, Kakimi, Kazuhiro, Nakajima, Jun, Funakoshi, Takeru, Iida, Shinsuke, Oka, Mikio, Shimamura, Teppei, Doi, Toshihiko, Doki, Yuichiro, Nakayama, Eiichi, Ueda, Ryuzo, Nishikawa, Hiroyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671535/
https://www.ncbi.nlm.nih.gov/pubmed/34907192
http://dx.doi.org/10.1038/s41467-021-27574-0

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