Cellular and Molecular Mechanism of Traditional Chinese Medicine on Ventricular Remodeling

Ventricular remodeling is related to the renin-angiotensin-aldosterone system, immune system, and various cytokines involved in inflammation, apoptosis, and cell signal regulation. Accumulated studies have shown that traditional Chinese medicine can significantly inhibit the process of ventricular r...

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Detalles Bibliográficos
Autores principales: Zhu, Yong-Chun, Liang, Bo, Gu, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671630/
https://www.ncbi.nlm.nih.gov/pubmed/34926607
http://dx.doi.org/10.3389/fcvm.2021.753095
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author Zhu, Yong-Chun
Liang, Bo
Gu, Ning
author_facet Zhu, Yong-Chun
Liang, Bo
Gu, Ning
author_sort Zhu, Yong-Chun
collection PubMed
description Ventricular remodeling is related to the renin-angiotensin-aldosterone system, immune system, and various cytokines involved in inflammation, apoptosis, and cell signal regulation. Accumulated studies have shown that traditional Chinese medicine can significantly inhibit the process of ventricular remodeling, which may be related to the mechanism mentioned above. Here, we conducted a system overview to critically review the cellular and molecular mechanism of traditional Chinese medicine on ventricular remodeling. We mainly searched PubMed for basic research about the anti-ventricular remodeling of traditional Chinese medicine in 5 recent years, and then objectively summarized these researches. We included more than 25 kinds of Chinese herbal medicines including Qi-Li-Qian-Xin, Qi-Shen-Yi-Qi Pill, Xin-Ji-Er-Kang Formula, and Yi-Qi-Wen-Yang Decoction, and found that they can inhibit ventricular remodeling effectively through multi-components and multi-action targets, which are promoting the clinical application of traditional Chinese medicine.
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spelling pubmed-86716302021-12-16 Cellular and Molecular Mechanism of Traditional Chinese Medicine on Ventricular Remodeling Zhu, Yong-Chun Liang, Bo Gu, Ning Front Cardiovasc Med Cardiovascular Medicine Ventricular remodeling is related to the renin-angiotensin-aldosterone system, immune system, and various cytokines involved in inflammation, apoptosis, and cell signal regulation. Accumulated studies have shown that traditional Chinese medicine can significantly inhibit the process of ventricular remodeling, which may be related to the mechanism mentioned above. Here, we conducted a system overview to critically review the cellular and molecular mechanism of traditional Chinese medicine on ventricular remodeling. We mainly searched PubMed for basic research about the anti-ventricular remodeling of traditional Chinese medicine in 5 recent years, and then objectively summarized these researches. We included more than 25 kinds of Chinese herbal medicines including Qi-Li-Qian-Xin, Qi-Shen-Yi-Qi Pill, Xin-Ji-Er-Kang Formula, and Yi-Qi-Wen-Yang Decoction, and found that they can inhibit ventricular remodeling effectively through multi-components and multi-action targets, which are promoting the clinical application of traditional Chinese medicine. Frontiers Media S.A. 2021-12-01 /pmc/articles/PMC8671630/ /pubmed/34926607 http://dx.doi.org/10.3389/fcvm.2021.753095 Text en Copyright © 2021 Zhu, Liang and Gu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Zhu, Yong-Chun
Liang, Bo
Gu, Ning
Cellular and Molecular Mechanism of Traditional Chinese Medicine on Ventricular Remodeling
title Cellular and Molecular Mechanism of Traditional Chinese Medicine on Ventricular Remodeling
title_full Cellular and Molecular Mechanism of Traditional Chinese Medicine on Ventricular Remodeling
title_fullStr Cellular and Molecular Mechanism of Traditional Chinese Medicine on Ventricular Remodeling
title_full_unstemmed Cellular and Molecular Mechanism of Traditional Chinese Medicine on Ventricular Remodeling
title_short Cellular and Molecular Mechanism of Traditional Chinese Medicine on Ventricular Remodeling
title_sort cellular and molecular mechanism of traditional chinese medicine on ventricular remodeling
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671630/
https://www.ncbi.nlm.nih.gov/pubmed/34926607
http://dx.doi.org/10.3389/fcvm.2021.753095
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