Intracellular RNase activity dampens zinc finger nuclease-mediated gene editing in hematopoietic stem and progenitor cells

Over the past decade, numerous gene-editing platforms which alter host DNA in a highly specific and targeted fashion have been described. Two notable examples are zinc finger nucleases (ZFNs), the first gene-editing platform to be tested in clinical trials, and more recently, CRISPR/Cas9. Although C...

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Detalles Bibliográficos
Autores principales: Peterson, Christopher W., Venkataraman, Rasika, Reddy, Sowmya S., Pande, Dnyanada, Enstrom, Mark R., Radtke, Stefan, Humbert, Olivier, Kiem, Hans-Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671732/
https://www.ncbi.nlm.nih.gov/pubmed/34977270
http://dx.doi.org/10.1016/j.omtm.2021.11.010

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