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Longitudinal changes in brain parenchyma due to mild traumatic brain injury during the first year after injury
Chronic gray matter (GM) atrophy is a known consequence of moderate and severe traumatic brain injuries but has not been consistently shown in mild traumatic brain injury (mTBI). The aim of this study was to investigate the longitudinal effect of uncomplicated mTBI on the brain's GM and white m...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671787/ https://www.ncbi.nlm.nih.gov/pubmed/34710284 http://dx.doi.org/10.1002/brb3.2410 |
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author | Muller, Angela M. Panenka, William J. Lange, Rael T. Iverson, Grant L. Brubacher, Jeffrey R. Virji‐Babul, Naznin |
author_facet | Muller, Angela M. Panenka, William J. Lange, Rael T. Iverson, Grant L. Brubacher, Jeffrey R. Virji‐Babul, Naznin |
author_sort | Muller, Angela M. |
collection | PubMed |
description | Chronic gray matter (GM) atrophy is a known consequence of moderate and severe traumatic brain injuries but has not been consistently shown in mild traumatic brain injury (mTBI). The aim of this study was to investigate the longitudinal effect of uncomplicated mTBI on the brain's GM and white matter (WM) from 6 weeks to 12 months after injury. Voxel‐based‐morphometry (VBM) was computed with the T1‐weighted images of 48 uncomplicated mTBI patients and 37 orthopedic controls. Over the period from 6 weeks to 12 months, only patients who experienced uncomplicated mTBI, but not control participants, showed significant GM decrease predominantly in the right hemisphere along the GM‐CSF border in lateral and medial portions of the sensorimotor cortex extending into the rolandic operculum, middle frontal gyrus, insula, and temporal pole. Additionally, only mTBI patients, but not controls, experienced significant WM decrease predominantly in the right hemisphere in the superior fasciculus longitudinalis, arcuate fasciculus, and cortical‐pontine tracts as well as a significant WM increase in left arcuate fasciculus and left capsula extrema. We did not observe any significant change in the controls for the same time interval or any significant group differences in GM and WM probability at each of the two timepoints. This suggests that the changes along the brain tissue borders observed in the mTBI group represent a reorganization associated with subtle microscopical changes in intracortical myelin and not a direct degenerative process as a result of mTBI. |
format | Online Article Text |
id | pubmed-8671787 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86717872021-12-21 Longitudinal changes in brain parenchyma due to mild traumatic brain injury during the first year after injury Muller, Angela M. Panenka, William J. Lange, Rael T. Iverson, Grant L. Brubacher, Jeffrey R. Virji‐Babul, Naznin Brain Behav Original Articles Chronic gray matter (GM) atrophy is a known consequence of moderate and severe traumatic brain injuries but has not been consistently shown in mild traumatic brain injury (mTBI). The aim of this study was to investigate the longitudinal effect of uncomplicated mTBI on the brain's GM and white matter (WM) from 6 weeks to 12 months after injury. Voxel‐based‐morphometry (VBM) was computed with the T1‐weighted images of 48 uncomplicated mTBI patients and 37 orthopedic controls. Over the period from 6 weeks to 12 months, only patients who experienced uncomplicated mTBI, but not control participants, showed significant GM decrease predominantly in the right hemisphere along the GM‐CSF border in lateral and medial portions of the sensorimotor cortex extending into the rolandic operculum, middle frontal gyrus, insula, and temporal pole. Additionally, only mTBI patients, but not controls, experienced significant WM decrease predominantly in the right hemisphere in the superior fasciculus longitudinalis, arcuate fasciculus, and cortical‐pontine tracts as well as a significant WM increase in left arcuate fasciculus and left capsula extrema. We did not observe any significant change in the controls for the same time interval or any significant group differences in GM and WM probability at each of the two timepoints. This suggests that the changes along the brain tissue borders observed in the mTBI group represent a reorganization associated with subtle microscopical changes in intracortical myelin and not a direct degenerative process as a result of mTBI. John Wiley and Sons Inc. 2021-10-28 /pmc/articles/PMC8671787/ /pubmed/34710284 http://dx.doi.org/10.1002/brb3.2410 Text en © 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Muller, Angela M. Panenka, William J. Lange, Rael T. Iverson, Grant L. Brubacher, Jeffrey R. Virji‐Babul, Naznin Longitudinal changes in brain parenchyma due to mild traumatic brain injury during the first year after injury |
title | Longitudinal changes in brain parenchyma due to mild traumatic brain injury during the first year after injury |
title_full | Longitudinal changes in brain parenchyma due to mild traumatic brain injury during the first year after injury |
title_fullStr | Longitudinal changes in brain parenchyma due to mild traumatic brain injury during the first year after injury |
title_full_unstemmed | Longitudinal changes in brain parenchyma due to mild traumatic brain injury during the first year after injury |
title_short | Longitudinal changes in brain parenchyma due to mild traumatic brain injury during the first year after injury |
title_sort | longitudinal changes in brain parenchyma due to mild traumatic brain injury during the first year after injury |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671787/ https://www.ncbi.nlm.nih.gov/pubmed/34710284 http://dx.doi.org/10.1002/brb3.2410 |
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