Assessing the presence of oligoclonal IgM bands as a prognostic biomarker of cognitive decline in the early stages of multiple sclerosis

BACKGROUND: An association has been found between the presence of lipid‐specific oligoclonal IgM bands (LS‐OCMB) in cerebrospinal fluid and a more severe clinical multiple sclerosis course. OBJECTIVE: To investigate lipid‐specific oligoclonal IgM bands as a prognostic biomarker of cognitive impairme...

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Detalles Bibliográficos
Autores principales: Coll‐Martinez, Clàudia, Quintana, Ester, Salavedra‐Pont, Judit, Buxó, Maria, González‐del‐Rio, Marina, Gómez, Immaculada, Muñoz‐San Martín, María, Villar, Luisa María, Álvarez‐Bravo, Gary, Robles‐Cedeño, René, Ramió‐Torrentà, Lluís, Gich, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671794/
https://www.ncbi.nlm.nih.gov/pubmed/34796675
http://dx.doi.org/10.1002/brb3.2405
Descripción
Sumario:BACKGROUND: An association has been found between the presence of lipid‐specific oligoclonal IgM bands (LS‐OCMB) in cerebrospinal fluid and a more severe clinical multiple sclerosis course. OBJECTIVE: To investigate lipid‐specific oligoclonal IgM bands as a prognostic biomarker of cognitive impairment in the early stages of multiple sclerosis. METHODS: Forty‐four patients underwent neuropsychological assessment at baseline and 4 years. Cognitive performance at follow‐up was compared adjusting by age, education, anxiety–depression, and baseline performance. RESULTS: LS‐OCMB+ patients only performed worse for Long‐Term Storage in the Selective Reminding Test (p = .018). CONCLUSION: There are no remarkable cognitive differences between LS‐OCMB– and LS‐OCMB+ patients in the early stages of MS.

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