Cargando…
Body Mass Index, Diabetes, and Risk of Tuberculosis: A Retrospective Cohort Study
Although both diabetes mellitus (DM) and underweight are associated with increased risk of tuberculosis (TB), there are limited data evaluating TB risk while considering two factors simultaneously—body mass index (BMI) and DM. A retrospective cohort study was performed with 10,087,903 participants o...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671831/ https://www.ncbi.nlm.nih.gov/pubmed/34926543 http://dx.doi.org/10.3389/fnut.2021.739766 |
_version_ | 1784615225789513728 |
---|---|
author | Choi, Hayoung Yoo, Jung Eun Han, Kyungdo Choi, Wonsuk Rhee, Sang Youl Lee, Hyun Shin, Dong Wook |
author_facet | Choi, Hayoung Yoo, Jung Eun Han, Kyungdo Choi, Wonsuk Rhee, Sang Youl Lee, Hyun Shin, Dong Wook |
author_sort | Choi, Hayoung |
collection | PubMed |
description | Although both diabetes mellitus (DM) and underweight are associated with increased risk of tuberculosis (TB), there are limited data evaluating TB risk while considering two factors simultaneously—body mass index (BMI) and DM. A retrospective cohort study was performed with 10,087,903 participants of the Korean National Health Screening Program in 2009. The cohort was followed up to the date of TB incidence, death, or until December 31, 2018. We compared the incidence and risk of TB according to BMI category and DM. During the 7.3-year follow-up duration, the incidence of TB was 0.92 per 1,000 person-years in the normal weight without DM, 2.26 in the normal weight with DM, 1.80 in the underweight without DM, and 5.35 in the underweight with DM. Compared to the normal weight without DM, the normal weight with DM, the underweight without DM, and the underweight with DM showed a 1.51-fold (95% CI, 1.46–1.57), a 2.21-fold (95% CI, 2.14–2.28), and a 3.24-fold (95% CI, 2.95–3.56) increased risk of TB, respectively. However, compared to the normal weight without DM, the severely obese without DM and those with DM showed a 0.37 (95% CI, 0.36–0.38) and a 0.42 (95% CI, 0.36–0.48)-fold decreased risk of TB, respectively. There was no significant joint effect of BMI and DM on the risk of incident TB in the overall population; a synergistic effect of underweight and DM was evident in participants <65 years of age, current smokers, and heavy drinkers. In conclusion, being underweight or DM individually increases the risk of incident TB. Based on our study results, a focused screening of incident TB in patients with DM may be beneficial. |
format | Online Article Text |
id | pubmed-8671831 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86718312021-12-16 Body Mass Index, Diabetes, and Risk of Tuberculosis: A Retrospective Cohort Study Choi, Hayoung Yoo, Jung Eun Han, Kyungdo Choi, Wonsuk Rhee, Sang Youl Lee, Hyun Shin, Dong Wook Front Nutr Nutrition Although both diabetes mellitus (DM) and underweight are associated with increased risk of tuberculosis (TB), there are limited data evaluating TB risk while considering two factors simultaneously—body mass index (BMI) and DM. A retrospective cohort study was performed with 10,087,903 participants of the Korean National Health Screening Program in 2009. The cohort was followed up to the date of TB incidence, death, or until December 31, 2018. We compared the incidence and risk of TB according to BMI category and DM. During the 7.3-year follow-up duration, the incidence of TB was 0.92 per 1,000 person-years in the normal weight without DM, 2.26 in the normal weight with DM, 1.80 in the underweight without DM, and 5.35 in the underweight with DM. Compared to the normal weight without DM, the normal weight with DM, the underweight without DM, and the underweight with DM showed a 1.51-fold (95% CI, 1.46–1.57), a 2.21-fold (95% CI, 2.14–2.28), and a 3.24-fold (95% CI, 2.95–3.56) increased risk of TB, respectively. However, compared to the normal weight without DM, the severely obese without DM and those with DM showed a 0.37 (95% CI, 0.36–0.38) and a 0.42 (95% CI, 0.36–0.48)-fold decreased risk of TB, respectively. There was no significant joint effect of BMI and DM on the risk of incident TB in the overall population; a synergistic effect of underweight and DM was evident in participants <65 years of age, current smokers, and heavy drinkers. In conclusion, being underweight or DM individually increases the risk of incident TB. Based on our study results, a focused screening of incident TB in patients with DM may be beneficial. Frontiers Media S.A. 2021-12-01 /pmc/articles/PMC8671831/ /pubmed/34926543 http://dx.doi.org/10.3389/fnut.2021.739766 Text en Copyright © 2021 Choi, Yoo, Han, Choi, Rhee, Lee and Shin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Choi, Hayoung Yoo, Jung Eun Han, Kyungdo Choi, Wonsuk Rhee, Sang Youl Lee, Hyun Shin, Dong Wook Body Mass Index, Diabetes, and Risk of Tuberculosis: A Retrospective Cohort Study |
title | Body Mass Index, Diabetes, and Risk of Tuberculosis: A Retrospective Cohort Study |
title_full | Body Mass Index, Diabetes, and Risk of Tuberculosis: A Retrospective Cohort Study |
title_fullStr | Body Mass Index, Diabetes, and Risk of Tuberculosis: A Retrospective Cohort Study |
title_full_unstemmed | Body Mass Index, Diabetes, and Risk of Tuberculosis: A Retrospective Cohort Study |
title_short | Body Mass Index, Diabetes, and Risk of Tuberculosis: A Retrospective Cohort Study |
title_sort | body mass index, diabetes, and risk of tuberculosis: a retrospective cohort study |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671831/ https://www.ncbi.nlm.nih.gov/pubmed/34926543 http://dx.doi.org/10.3389/fnut.2021.739766 |
work_keys_str_mv | AT choihayoung bodymassindexdiabetesandriskoftuberculosisaretrospectivecohortstudy AT yoojungeun bodymassindexdiabetesandriskoftuberculosisaretrospectivecohortstudy AT hankyungdo bodymassindexdiabetesandriskoftuberculosisaretrospectivecohortstudy AT choiwonsuk bodymassindexdiabetesandriskoftuberculosisaretrospectivecohortstudy AT rheesangyoul bodymassindexdiabetesandriskoftuberculosisaretrospectivecohortstudy AT leehyun bodymassindexdiabetesandriskoftuberculosisaretrospectivecohortstudy AT shindongwook bodymassindexdiabetesandriskoftuberculosisaretrospectivecohortstudy |