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Feasibility of Booster Vaccination in High-Risk Populations for Controlling Coronavirus Variants — China, 2021

INTRODUCTION: Vaccination booster shots are completely necessary for controlling breakthrough infections of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China. The study aims to estimate effectiveness of booster vaccines for high-risk populations (HRPs). METHODS: A vaccinated Susc...

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Detalles Bibliográficos
Autores principales: Li, Kangguo, Zhao, Zeyu, Wei, Hongjie, Rui, Jia, Huang, Jiefeng, Guo, Xiaohao, Guo, Yichao, Yang, Shiting, Abudurusuli, Guzainuer, Luo, Li, Liu, Xingchun, Wang, Yao, Xu, Jingwen, Zhu, Yuanzhao, Yang, Meng, Yang, Tianlong, Liu, Weikang, Deng, Bin, Liu, Chan, Li, Zhuoyang, Li, Peihua, Yu, Shanshan, Yang, Zimei, Su, Yanhua, Zhao, Benhua, Niu, Yan, Chen, Tianmu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Office of CCDCW, Chinese Center for Disease Control and Prevention 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671839/
https://www.ncbi.nlm.nih.gov/pubmed/34934519
http://dx.doi.org/10.46234/ccdcw2021.259
Descripción
Sumario:INTRODUCTION: Vaccination booster shots are completely necessary for controlling breakthrough infections of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China. The study aims to estimate effectiveness of booster vaccines for high-risk populations (HRPs). METHODS: A vaccinated Susceptible-Exposed-Symptomatic-Asymptomatic-Recovered/Removed (SEIAR) model was developed to simulate scenarios of effective reproduction number (R(eff)) from 4 to 6. Total number of infectious and asymptomatic cases were used to evaluated vaccination effectiveness. RESULTS: Our model showed that we could not prevent outbreaks when covering 80% of HRPs with booster unless R(eff)=4.0 or the booster vaccine had efficacy against infectivity and susceptibility of more than 90%. The results were consistent when the outcome index was confirmed cases or asymptomatic cases. CONCLUSIONS: An ideal coronavirus disease 2019 (COVID-19) booster vaccination strategy for HRPs would be expected to reach the initial goal to control the transmission of the Delta variant in China. Accordingly, the recommendation for the COVID-19 booster vaccine should be implemented in HRPs who are already vaccinated and could prevent transmission to other groups.