Sarcoidosis‐like reaction after neoadjuvant pembrolizumab combined with chemotherapy mimicking disease progression of NSCLC induced encouraging discovery of pathological complete response

Neoadjuvant chemoimmunotherapy has demonstrated improved efficacy and prognosis in stage IIa–IIIb patients with non‐small cell lung cancer (NSCLC). Drug‐induced sarcoidosis‐like reaction (DISR), an autoimmune reaction, has been reported as a type of immune‐related adverse event that may mimic diseas...

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, Yuequan, Li, Ji, Chen, Minjiang, Liu, Hongsheng, Ma, Dongjie, Lin, Yuxiao, Wang, Mengzhao, Xu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671890/
https://www.ncbi.nlm.nih.gov/pubmed/34761878
http://dx.doi.org/10.1111/1759-7714.14228
_version_ 1784615242191339520
author Shi, Yuequan
Li, Ji
Chen, Minjiang
Liu, Hongsheng
Ma, Dongjie
Lin, Yuxiao
Wang, Mengzhao
Xu, Yan
author_facet Shi, Yuequan
Li, Ji
Chen, Minjiang
Liu, Hongsheng
Ma, Dongjie
Lin, Yuxiao
Wang, Mengzhao
Xu, Yan
author_sort Shi, Yuequan
collection PubMed
description Neoadjuvant chemoimmunotherapy has demonstrated improved efficacy and prognosis in stage IIa–IIIb patients with non‐small cell lung cancer (NSCLC). Drug‐induced sarcoidosis‐like reaction (DISR), an autoimmune reaction, has been reported as a type of immune‐related adverse event that may mimic disease progression. Here, we report the case of patient with NSCLC who developed DISR during neoadjuvant chemoimmunotherapy and finally achieved pathological complete response after surgery.
format Online
Article
Text
id pubmed-8671890
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley & Sons Australia, Ltd
record_format MEDLINE/PubMed
spelling pubmed-86718902021-12-21 Sarcoidosis‐like reaction after neoadjuvant pembrolizumab combined with chemotherapy mimicking disease progression of NSCLC induced encouraging discovery of pathological complete response Shi, Yuequan Li, Ji Chen, Minjiang Liu, Hongsheng Ma, Dongjie Lin, Yuxiao Wang, Mengzhao Xu, Yan Thorac Cancer Case Reports Neoadjuvant chemoimmunotherapy has demonstrated improved efficacy and prognosis in stage IIa–IIIb patients with non‐small cell lung cancer (NSCLC). Drug‐induced sarcoidosis‐like reaction (DISR), an autoimmune reaction, has been reported as a type of immune‐related adverse event that may mimic disease progression. Here, we report the case of patient with NSCLC who developed DISR during neoadjuvant chemoimmunotherapy and finally achieved pathological complete response after surgery. John Wiley & Sons Australia, Ltd 2021-11-11 2021-12 /pmc/articles/PMC8671890/ /pubmed/34761878 http://dx.doi.org/10.1111/1759-7714.14228 Text en © 2021 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Shi, Yuequan
Li, Ji
Chen, Minjiang
Liu, Hongsheng
Ma, Dongjie
Lin, Yuxiao
Wang, Mengzhao
Xu, Yan
Sarcoidosis‐like reaction after neoadjuvant pembrolizumab combined with chemotherapy mimicking disease progression of NSCLC induced encouraging discovery of pathological complete response
title Sarcoidosis‐like reaction after neoadjuvant pembrolizumab combined with chemotherapy mimicking disease progression of NSCLC induced encouraging discovery of pathological complete response
title_full Sarcoidosis‐like reaction after neoadjuvant pembrolizumab combined with chemotherapy mimicking disease progression of NSCLC induced encouraging discovery of pathological complete response
title_fullStr Sarcoidosis‐like reaction after neoadjuvant pembrolizumab combined with chemotherapy mimicking disease progression of NSCLC induced encouraging discovery of pathological complete response
title_full_unstemmed Sarcoidosis‐like reaction after neoadjuvant pembrolizumab combined with chemotherapy mimicking disease progression of NSCLC induced encouraging discovery of pathological complete response
title_short Sarcoidosis‐like reaction after neoadjuvant pembrolizumab combined with chemotherapy mimicking disease progression of NSCLC induced encouraging discovery of pathological complete response
title_sort sarcoidosis‐like reaction after neoadjuvant pembrolizumab combined with chemotherapy mimicking disease progression of nsclc induced encouraging discovery of pathological complete response
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671890/
https://www.ncbi.nlm.nih.gov/pubmed/34761878
http://dx.doi.org/10.1111/1759-7714.14228
work_keys_str_mv AT shiyuequan sarcoidosislikereactionafterneoadjuvantpembrolizumabcombinedwithchemotherapymimickingdiseaseprogressionofnsclcinducedencouragingdiscoveryofpathologicalcompleteresponse
AT liji sarcoidosislikereactionafterneoadjuvantpembrolizumabcombinedwithchemotherapymimickingdiseaseprogressionofnsclcinducedencouragingdiscoveryofpathologicalcompleteresponse
AT chenminjiang sarcoidosislikereactionafterneoadjuvantpembrolizumabcombinedwithchemotherapymimickingdiseaseprogressionofnsclcinducedencouragingdiscoveryofpathologicalcompleteresponse
AT liuhongsheng sarcoidosislikereactionafterneoadjuvantpembrolizumabcombinedwithchemotherapymimickingdiseaseprogressionofnsclcinducedencouragingdiscoveryofpathologicalcompleteresponse
AT madongjie sarcoidosislikereactionafterneoadjuvantpembrolizumabcombinedwithchemotherapymimickingdiseaseprogressionofnsclcinducedencouragingdiscoveryofpathologicalcompleteresponse
AT linyuxiao sarcoidosislikereactionafterneoadjuvantpembrolizumabcombinedwithchemotherapymimickingdiseaseprogressionofnsclcinducedencouragingdiscoveryofpathologicalcompleteresponse
AT wangmengzhao sarcoidosislikereactionafterneoadjuvantpembrolizumabcombinedwithchemotherapymimickingdiseaseprogressionofnsclcinducedencouragingdiscoveryofpathologicalcompleteresponse
AT xuyan sarcoidosislikereactionafterneoadjuvantpembrolizumabcombinedwithchemotherapymimickingdiseaseprogressionofnsclcinducedencouragingdiscoveryofpathologicalcompleteresponse

Ejemplares similares