The structural basis for high affinity binding of α1-acid glycoprotein to the potent antitumor compound UCN-01

The α1-acid glycoprotein (AGP) is an abundant blood plasma protein with important immunomodulatory functions coupled to endogenous and exogenous ligand-binding properties. Its affinity for many drug-like structures, however, means AGP can have a significant effect on the pharmokinetics and pharmacod...

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Detalles Bibliográficos
Autores principales: Landin, Erik J.B., Williams, Christopher, Ryan, Sara A., Bochel, Alice, Akter, Nahida, Redfield, Christina, Sessions, Richard B., Dedi, Neesha, Taylor, Richard J., Crump, Matthew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671939/
https://www.ncbi.nlm.nih.gov/pubmed/34758357
http://dx.doi.org/10.1016/j.jbc.2021.101392

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