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Near-infrared probes for luminescence lifetime imaging

Biomedical luminescence imaging in the near-infrared (NIR, 700-1700 nm) region has shown great potential in visualizing biological processes and pathological conditions at cellular and animal levels, owing to the reduced tissue absorption and scattering compared to light in the visible (400-700 nm)...

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Detalles Bibliográficos
Autores principales: Li, Benhao, Lin, Jing, Huang, Peng, Chen, Xiaoyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671960/
https://www.ncbi.nlm.nih.gov/pubmed/34976583
http://dx.doi.org/10.7150/ntno.63124
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author Li, Benhao
Lin, Jing
Huang, Peng
Chen, Xiaoyuan
author_facet Li, Benhao
Lin, Jing
Huang, Peng
Chen, Xiaoyuan
author_sort Li, Benhao
collection PubMed
description Biomedical luminescence imaging in the near-infrared (NIR, 700-1700 nm) region has shown great potential in visualizing biological processes and pathological conditions at cellular and animal levels, owing to the reduced tissue absorption and scattering compared to light in the visible (400-700 nm) region. To overcome the background interference and signal attenuation during intensity-based luminescence imaging, lifetime imaging has demonstrated a reliable imaging modality complementary to intensity measurement. Several selective or environment-responsive probes have been successfully developed for luminescence lifetime imaging and multiplex detection. This review summarizes recent advances in the application of luminescence lifetime imaging at cellular and animal levels in NIR-I and NIR-II regions. Finally, the challenges and further directions of luminescence lifetime imaging are also discussed.
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spelling pubmed-86719602022-01-01 Near-infrared probes for luminescence lifetime imaging Li, Benhao Lin, Jing Huang, Peng Chen, Xiaoyuan Nanotheranostics Review Biomedical luminescence imaging in the near-infrared (NIR, 700-1700 nm) region has shown great potential in visualizing biological processes and pathological conditions at cellular and animal levels, owing to the reduced tissue absorption and scattering compared to light in the visible (400-700 nm) region. To overcome the background interference and signal attenuation during intensity-based luminescence imaging, lifetime imaging has demonstrated a reliable imaging modality complementary to intensity measurement. Several selective or environment-responsive probes have been successfully developed for luminescence lifetime imaging and multiplex detection. This review summarizes recent advances in the application of luminescence lifetime imaging at cellular and animal levels in NIR-I and NIR-II regions. Finally, the challenges and further directions of luminescence lifetime imaging are also discussed. Ivyspring International Publisher 2022-01-01 /pmc/articles/PMC8671960/ /pubmed/34976583 http://dx.doi.org/10.7150/ntno.63124 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Li, Benhao
Lin, Jing
Huang, Peng
Chen, Xiaoyuan
Near-infrared probes for luminescence lifetime imaging
title Near-infrared probes for luminescence lifetime imaging
title_full Near-infrared probes for luminescence lifetime imaging
title_fullStr Near-infrared probes for luminescence lifetime imaging
title_full_unstemmed Near-infrared probes for luminescence lifetime imaging
title_short Near-infrared probes for luminescence lifetime imaging
title_sort near-infrared probes for luminescence lifetime imaging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671960/
https://www.ncbi.nlm.nih.gov/pubmed/34976583
http://dx.doi.org/10.7150/ntno.63124
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