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Inhibitors of the Bub1 spindle assembly checkpoint kinase: synthesis of BAY-320 and comparison with 2OH-BNPP1

Bub1 is a serine/threonine kinase proposed to function centrally in mitotic chromosome alignment and the spindle assembly checkpoint (SAC); however, its role remains controversial. Although it is well documented that Bub1 phosphorylation of Histone 2A at T120 (H2ApT120) recruits Sgo1/2 to kinetochor...

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Detalles Bibliográficos
Autores principales:	Amalina, Ilma, Bennett, Ailsa, Whalley, Helen, Perera, David, McGrail, Joanne C., Tighe, Anthony, Procter, David J., Taylor, Stephen S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2021
Materias:	Biochemistry, Cellular and Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672067/ https://www.ncbi.nlm.nih.gov/pubmed/34925867 http://dx.doi.org/10.1098/rsos.210854

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