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Genetic Liability to Insomnia and Lung Cancer Risk: A Mendelian Randomization Analysis

Lung cancer is the second most frequently diagnosed cancer and the leading cause of cancer death worldwide, making its prevention an urgent issue. Meanwhile, the estimated prevalence of insomnia was as high as 30% globally. Research on the causal effect of insomnia on lung cancer incidence is still...

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Autores principales: Shen, Jiayi, Zhou, Huaqiang, Liu, Jiaqing, Zhang, Yaxiong, Zhou, Ting, Chen, Gang, Fang, Wenfeng, Yang, Yunpeng, Huang, Yan, Zhang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672094/
https://www.ncbi.nlm.nih.gov/pubmed/34925448
http://dx.doi.org/10.3389/fgene.2021.756908
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author Shen, Jiayi
Zhou, Huaqiang
Liu, Jiaqing
Zhang, Yaxiong
Zhou, Ting
Chen, Gang
Fang, Wenfeng
Yang, Yunpeng
Huang, Yan
Zhang, Li
author_facet Shen, Jiayi
Zhou, Huaqiang
Liu, Jiaqing
Zhang, Yaxiong
Zhou, Ting
Chen, Gang
Fang, Wenfeng
Yang, Yunpeng
Huang, Yan
Zhang, Li
author_sort Shen, Jiayi
collection PubMed
description Lung cancer is the second most frequently diagnosed cancer and the leading cause of cancer death worldwide, making its prevention an urgent issue. Meanwhile, the estimated prevalence of insomnia was as high as 30% globally. Research on the causal effect of insomnia on lung cancer incidence is still lacking. In this study, we aimed to assess the causality between the genetic liability to insomnia and lung cancer. We performed a two-sample Mendelian randomization analysis (inverse variance weighted) to determine the causality between the genetic liability to insomnia and lung cancer. Subgroup analysis was conducted, which included lung adenocarcinoma and lung squamous cell carcinoma. In the sensitivity analysis, we conducted heterogeneity test, MR Egger, single SNP analysis, leave-one-out analysis, and MR PRESSO. There were causalities between the genetic susceptibility to insomnia and increased incidence of lung cancer [odds ratio (95% confidence interval), 1.35 (1.14–1.59); P, < 0.001], lung adenocarcinoma [odds ratio (95% confidence interval), 1.35 (1.07–1.70); P, 0.01], and lung squamous cell carcinoma [odds ratio (95% confidence interval), 1.35 (1.06–1.72), P, 0.02]. No violation of Mendelian randomization assumptions was observed in the sensitivity analysis. There was a causal relationship between the genetic susceptibility to insomnia and the lung cancer, which was also observed in lung adenocarcinoma and lung squamous cell carcinoma. The underlying mechanism remains unknown. Effective intervention and management for insomnia were recommended to improve the sleep quality and to prevent lung cancer. Moreover, regular screening for lung cancer may be beneficial for patients with insomnia.
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spelling pubmed-86720942021-12-16 Genetic Liability to Insomnia and Lung Cancer Risk: A Mendelian Randomization Analysis Shen, Jiayi Zhou, Huaqiang Liu, Jiaqing Zhang, Yaxiong Zhou, Ting Chen, Gang Fang, Wenfeng Yang, Yunpeng Huang, Yan Zhang, Li Front Genet Genetics Lung cancer is the second most frequently diagnosed cancer and the leading cause of cancer death worldwide, making its prevention an urgent issue. Meanwhile, the estimated prevalence of insomnia was as high as 30% globally. Research on the causal effect of insomnia on lung cancer incidence is still lacking. In this study, we aimed to assess the causality between the genetic liability to insomnia and lung cancer. We performed a two-sample Mendelian randomization analysis (inverse variance weighted) to determine the causality between the genetic liability to insomnia and lung cancer. Subgroup analysis was conducted, which included lung adenocarcinoma and lung squamous cell carcinoma. In the sensitivity analysis, we conducted heterogeneity test, MR Egger, single SNP analysis, leave-one-out analysis, and MR PRESSO. There were causalities between the genetic susceptibility to insomnia and increased incidence of lung cancer [odds ratio (95% confidence interval), 1.35 (1.14–1.59); P, < 0.001], lung adenocarcinoma [odds ratio (95% confidence interval), 1.35 (1.07–1.70); P, 0.01], and lung squamous cell carcinoma [odds ratio (95% confidence interval), 1.35 (1.06–1.72), P, 0.02]. No violation of Mendelian randomization assumptions was observed in the sensitivity analysis. There was a causal relationship between the genetic susceptibility to insomnia and the lung cancer, which was also observed in lung adenocarcinoma and lung squamous cell carcinoma. The underlying mechanism remains unknown. Effective intervention and management for insomnia were recommended to improve the sleep quality and to prevent lung cancer. Moreover, regular screening for lung cancer may be beneficial for patients with insomnia. Frontiers Media S.A. 2021-12-01 /pmc/articles/PMC8672094/ /pubmed/34925448 http://dx.doi.org/10.3389/fgene.2021.756908 Text en Copyright © 2021 Shen, Zhou, Liu, Zhang, Zhou, Chen, Fang, Yang, Huang and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Shen, Jiayi
Zhou, Huaqiang
Liu, Jiaqing
Zhang, Yaxiong
Zhou, Ting
Chen, Gang
Fang, Wenfeng
Yang, Yunpeng
Huang, Yan
Zhang, Li
Genetic Liability to Insomnia and Lung Cancer Risk: A Mendelian Randomization Analysis
title Genetic Liability to Insomnia and Lung Cancer Risk: A Mendelian Randomization Analysis
title_full Genetic Liability to Insomnia and Lung Cancer Risk: A Mendelian Randomization Analysis
title_fullStr Genetic Liability to Insomnia and Lung Cancer Risk: A Mendelian Randomization Analysis
title_full_unstemmed Genetic Liability to Insomnia and Lung Cancer Risk: A Mendelian Randomization Analysis
title_short Genetic Liability to Insomnia and Lung Cancer Risk: A Mendelian Randomization Analysis
title_sort genetic liability to insomnia and lung cancer risk: a mendelian randomization analysis
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672094/
https://www.ncbi.nlm.nih.gov/pubmed/34925448
http://dx.doi.org/10.3389/fgene.2021.756908
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