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A rare case of polypoid primary anorectal melanoma with subsequent giant stomach metastasis: A gastrointestinal involvement of both primary and metastatic mucosal melanoma

Melanoma can involve the gastrointestinal apparatus as both primary and metastatic lesions. Primary anorectal mucosal melanoma (ARMM) and metastatic gastric melanoma are rare entities and usually resulted in a poor prognosis. We presented a case of a 61-year-old man who after the complete excision o...

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Autores principales: De Giorgi, Vincenzo, Scarfì, Federica, Boselli, Carlo, Sacchetti, Giacomo, Natalizi, Nicola, Castellani, Danilo, Covarelli, Piero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672120/
https://www.ncbi.nlm.nih.gov/pubmed/35003567
http://dx.doi.org/10.4081/dr.2021.9092
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author De Giorgi, Vincenzo
Scarfì, Federica
Boselli, Carlo
Sacchetti, Giacomo
Natalizi, Nicola
Castellani, Danilo
Covarelli, Piero
author_facet De Giorgi, Vincenzo
Scarfì, Federica
Boselli, Carlo
Sacchetti, Giacomo
Natalizi, Nicola
Castellani, Danilo
Covarelli, Piero
author_sort De Giorgi, Vincenzo
collection PubMed
description Melanoma can involve the gastrointestinal apparatus as both primary and metastatic lesions. Primary anorectal mucosal melanoma (ARMM) and metastatic gastric melanoma are rare entities and usually resulted in a poor prognosis. We presented a case of a 61-year-old man who after the complete excision of an ARMM developed a gastric metastasis after almost three years form the complete tumour excision. Upon esophagogastroduodenoscopy, a giant ulcered mass resulted in melanoma metastasis. The patient underwent a near-total gastrectomy. After five months of follow-up, the patient is disease-free. The incidence of ARMMs is increasing, highlighting the necessity of new prevention and treatment strategies in order to achieve a better prognosis for these patients. There are no known risk factor for ARMMs but surgery, together with the combination of anti-CTLA-4 and anti-PD-1 antibodies, are promising therapeutic options. Early and aggressive treatments are required, together with a strict multidisciplinary approach.
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spelling pubmed-86721202022-01-06 A rare case of polypoid primary anorectal melanoma with subsequent giant stomach metastasis: A gastrointestinal involvement of both primary and metastatic mucosal melanoma De Giorgi, Vincenzo Scarfì, Federica Boselli, Carlo Sacchetti, Giacomo Natalizi, Nicola Castellani, Danilo Covarelli, Piero Dermatol Reports Case Report Melanoma can involve the gastrointestinal apparatus as both primary and metastatic lesions. Primary anorectal mucosal melanoma (ARMM) and metastatic gastric melanoma are rare entities and usually resulted in a poor prognosis. We presented a case of a 61-year-old man who after the complete excision of an ARMM developed a gastric metastasis after almost three years form the complete tumour excision. Upon esophagogastroduodenoscopy, a giant ulcered mass resulted in melanoma metastasis. The patient underwent a near-total gastrectomy. After five months of follow-up, the patient is disease-free. The incidence of ARMMs is increasing, highlighting the necessity of new prevention and treatment strategies in order to achieve a better prognosis for these patients. There are no known risk factor for ARMMs but surgery, together with the combination of anti-CTLA-4 and anti-PD-1 antibodies, are promising therapeutic options. Early and aggressive treatments are required, together with a strict multidisciplinary approach. PAGEPress Publications, Pavia, Italy 2021-07-28 /pmc/articles/PMC8672120/ /pubmed/35003567 http://dx.doi.org/10.4081/dr.2021.9092 Text en ©Copyright: the Author(s) https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution NonCommercial 4.0 License (CC BY-NC 4.0).
spellingShingle Case Report
De Giorgi, Vincenzo
Scarfì, Federica
Boselli, Carlo
Sacchetti, Giacomo
Natalizi, Nicola
Castellani, Danilo
Covarelli, Piero
A rare case of polypoid primary anorectal melanoma with subsequent giant stomach metastasis: A gastrointestinal involvement of both primary and metastatic mucosal melanoma
title A rare case of polypoid primary anorectal melanoma with subsequent giant stomach metastasis: A gastrointestinal involvement of both primary and metastatic mucosal melanoma
title_full A rare case of polypoid primary anorectal melanoma with subsequent giant stomach metastasis: A gastrointestinal involvement of both primary and metastatic mucosal melanoma
title_fullStr A rare case of polypoid primary anorectal melanoma with subsequent giant stomach metastasis: A gastrointestinal involvement of both primary and metastatic mucosal melanoma
title_full_unstemmed A rare case of polypoid primary anorectal melanoma with subsequent giant stomach metastasis: A gastrointestinal involvement of both primary and metastatic mucosal melanoma
title_short A rare case of polypoid primary anorectal melanoma with subsequent giant stomach metastasis: A gastrointestinal involvement of both primary and metastatic mucosal melanoma
title_sort rare case of polypoid primary anorectal melanoma with subsequent giant stomach metastasis: a gastrointestinal involvement of both primary and metastatic mucosal melanoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672120/
https://www.ncbi.nlm.nih.gov/pubmed/35003567
http://dx.doi.org/10.4081/dr.2021.9092
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