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Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”)
A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal Traits translational Network”) Working Group 2 present an overview of the routine techniques as well...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672201/ https://www.ncbi.nlm.nih.gov/pubmed/34925226 http://dx.doi.org/10.3389/fendo.2021.720728 |
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| author | Foessl, Ines Bassett, J. H. Duncan Bjørnerem, Åshild Busse, Björn Calado, Ângelo Chavassieux, Pascale Christou, Maria Douni, Eleni Fiedler, Imke A. K. Fonseca, João Eurico Hassler, Eva Högler, Wolfgang Kague, Erika Karasik, David Khashayar, Patricia Langdahl, Bente L. Leitch, Victoria D. Lopes, Philippe Markozannes, Georgios McGuigan, Fiona E. A. Medina-Gomez, Carolina Ntzani, Evangelia Oei, Ling Ohlsson, Claes Szulc, Pawel Tobias, Jonathan H. Trajanoska, Katerina Tuzun, Şansın Valjevac, Amina van Rietbergen, Bert Williams, Graham R. Zekic, Tatjana Rivadeneira, Fernando Obermayer-Pietsch, Barbara |
| author_facet | Foessl, Ines Bassett, J. H. Duncan Bjørnerem, Åshild Busse, Björn Calado, Ângelo Chavassieux, Pascale Christou, Maria Douni, Eleni Fiedler, Imke A. K. Fonseca, João Eurico Hassler, Eva Högler, Wolfgang Kague, Erika Karasik, David Khashayar, Patricia Langdahl, Bente L. Leitch, Victoria D. Lopes, Philippe Markozannes, Georgios McGuigan, Fiona E. A. Medina-Gomez, Carolina Ntzani, Evangelia Oei, Ling Ohlsson, Claes Szulc, Pawel Tobias, Jonathan H. Trajanoska, Katerina Tuzun, Şansın Valjevac, Amina van Rietbergen, Bert Williams, Graham R. Zekic, Tatjana Rivadeneira, Fernando Obermayer-Pietsch, Barbara |
| author_sort | Foessl, Ines |
| collection | PubMed |
| description | A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal Traits translational Network”) Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals – including their strengths and weaknesses. New research methodologies are outlined and future strategies are discussed to combine phenotypic with rapidly developing –omics data in order to advance musculoskeletal research and move towards “personalised medicine”. |
| format | Online Article Text |
| id | pubmed-8672201 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Frontiers Media S.A. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-86722012021-12-16 Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”) Foessl, Ines Bassett, J. H. Duncan Bjørnerem, Åshild Busse, Björn Calado, Ângelo Chavassieux, Pascale Christou, Maria Douni, Eleni Fiedler, Imke A. K. Fonseca, João Eurico Hassler, Eva Högler, Wolfgang Kague, Erika Karasik, David Khashayar, Patricia Langdahl, Bente L. Leitch, Victoria D. Lopes, Philippe Markozannes, Georgios McGuigan, Fiona E. A. Medina-Gomez, Carolina Ntzani, Evangelia Oei, Ling Ohlsson, Claes Szulc, Pawel Tobias, Jonathan H. Trajanoska, Katerina Tuzun, Şansın Valjevac, Amina van Rietbergen, Bert Williams, Graham R. Zekic, Tatjana Rivadeneira, Fernando Obermayer-Pietsch, Barbara Front Endocrinol (Lausanne) Endocrinology A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal Traits translational Network”) Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals – including their strengths and weaknesses. New research methodologies are outlined and future strategies are discussed to combine phenotypic with rapidly developing –omics data in order to advance musculoskeletal research and move towards “personalised medicine”. Frontiers Media S.A. 2021-12-01 /pmc/articles/PMC8672201/ /pubmed/34925226 http://dx.doi.org/10.3389/fendo.2021.720728 Text en Copyright © 2021 Foessl, Bassett, Bjørnerem, Busse, Calado, Chavassieux, Christou, Douni, Fiedler, Fonseca, Hassler, Högler, Kague, Karasik, Khashayar, Langdahl, Leitch, Lopes, Markozannes, McGuigan, Medina-Gomez, Ntzani, Oei, Ohlsson, Szulc, Tobias, Trajanoska, Tuzun, Valjevac, van Rietbergen, Williams, Zekic, Rivadeneira and Obermayer-Pietsch https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| spellingShingle | Endocrinology Foessl, Ines Bassett, J. H. Duncan Bjørnerem, Åshild Busse, Björn Calado, Ângelo Chavassieux, Pascale Christou, Maria Douni, Eleni Fiedler, Imke A. K. Fonseca, João Eurico Hassler, Eva Högler, Wolfgang Kague, Erika Karasik, David Khashayar, Patricia Langdahl, Bente L. Leitch, Victoria D. Lopes, Philippe Markozannes, Georgios McGuigan, Fiona E. A. Medina-Gomez, Carolina Ntzani, Evangelia Oei, Ling Ohlsson, Claes Szulc, Pawel Tobias, Jonathan H. Trajanoska, Katerina Tuzun, Şansın Valjevac, Amina van Rietbergen, Bert Williams, Graham R. Zekic, Tatjana Rivadeneira, Fernando Obermayer-Pietsch, Barbara Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”) |
| title | Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”) |
| title_full | Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”) |
| title_fullStr | Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”) |
| title_full_unstemmed | Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”) |
| title_short | Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”) |
| title_sort | bone phenotyping approaches in human, mice and zebrafish – expert overview of the eu cost action gemstone (“genomics of musculoskeletal traits translational network”) |
| topic | Endocrinology |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672201/ https://www.ncbi.nlm.nih.gov/pubmed/34925226 http://dx.doi.org/10.3389/fendo.2021.720728 |
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