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The DNMT1 inhibitor GSK-3484862 mediates global demethylation in murine embryonic stem cells

BACKGROUND: DNA methylation plays an important role in regulating gene expression in mammals. The covalent DNMT1 inhibitors 5-azacytidine and decitabine are widely used in research to reduce DNA methylation levels, but they impart severe cytotoxicity which limits their demethylation capability and c...

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Detalles Bibliográficos
Autores principales:	Azevedo Portilho, Nathalia, Saini, Deepak, Hossain, Ishtiaque, Sirois, Jacinthe, Moraes, Christopher, Pastor, William A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672470/ https://www.ncbi.nlm.nih.gov/pubmed/34906184 http://dx.doi.org/10.1186/s13072-021-00429-0

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