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Application of neck ultrasound in the diagnosis of sarcoidosis
OBJECTIVE: To explore the significance of neck ultrasound (NUS) combined with contrast-enhanced ultrasound (CEUS) in the diagnosis of sarcoidosis. METHODS: 88 patients with evidence of intrathoracic lymphadenopathy and suspected sarcoidosis with enlarged cervical lymph nodes underwent NUS, CEUS, fin...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672511/ https://www.ncbi.nlm.nih.gov/pubmed/34911526 http://dx.doi.org/10.1186/s12890-021-01769-z |
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author | Shen, Mengjun Zhou, Ying Gu, Weiqing Yin, Chengsheng Wang, Yin Zhang, Yuan |
author_facet | Shen, Mengjun Zhou, Ying Gu, Weiqing Yin, Chengsheng Wang, Yin Zhang, Yuan |
author_sort | Shen, Mengjun |
collection | PubMed |
description | OBJECTIVE: To explore the significance of neck ultrasound (NUS) combined with contrast-enhanced ultrasound (CEUS) in the diagnosis of sarcoidosis. METHODS: 88 patients with evidence of intrathoracic lymphadenopathy and suspected sarcoidosis with enlarged cervical lymph nodes underwent NUS, CEUS, fine-needle aspiration and core needle biopsy when technically feasible were retrospectively analyzed in this study. Seven characteristics such as enhanced mode (EM), resolution time, color Doppler flow imaging (CDFI), fading time, peaking state-uniformity, strengthen the area and symmetry were considered to perform the logistic regression model. RESULTS: Of 88 patients included in this study, sarcoidosis was accounted in 20 cases, tuberculosis in 23 cases, malignancy in 22 cases and inflammatory lymph node in 23 cases. There were statistically significant differences in symmetry, lymphatic hilum, homogeneity, CDFI pattern and elasticity score between the sarcoidosis and non-sarcoidosis groups via NUS. Similarly, we also acknowledged a statistically significant differences in EM, homogeneity, presence or absence of necrosis between the sarcoidosis and non-sarcoidosis groups via CEUS to further group the non-sarcoidosis into tuberculosis, malignancy or inflammatory disorder. The percentage correction of prediction was 90% (18/20). CONCLUSION: NUS combined with CEUS has characteristic features in sarcoidosis with cervical lymph node involvement, which is helpful for its diagnosis and differential diagnosis. The binary classification model of NUS combined with CEUS features can help differentiate sarcoidosis from non-sarcoidosis groups. |
format | Online Article Text |
id | pubmed-8672511 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-86725112021-12-15 Application of neck ultrasound in the diagnosis of sarcoidosis Shen, Mengjun Zhou, Ying Gu, Weiqing Yin, Chengsheng Wang, Yin Zhang, Yuan BMC Pulm Med Research OBJECTIVE: To explore the significance of neck ultrasound (NUS) combined with contrast-enhanced ultrasound (CEUS) in the diagnosis of sarcoidosis. METHODS: 88 patients with evidence of intrathoracic lymphadenopathy and suspected sarcoidosis with enlarged cervical lymph nodes underwent NUS, CEUS, fine-needle aspiration and core needle biopsy when technically feasible were retrospectively analyzed in this study. Seven characteristics such as enhanced mode (EM), resolution time, color Doppler flow imaging (CDFI), fading time, peaking state-uniformity, strengthen the area and symmetry were considered to perform the logistic regression model. RESULTS: Of 88 patients included in this study, sarcoidosis was accounted in 20 cases, tuberculosis in 23 cases, malignancy in 22 cases and inflammatory lymph node in 23 cases. There were statistically significant differences in symmetry, lymphatic hilum, homogeneity, CDFI pattern and elasticity score between the sarcoidosis and non-sarcoidosis groups via NUS. Similarly, we also acknowledged a statistically significant differences in EM, homogeneity, presence or absence of necrosis between the sarcoidosis and non-sarcoidosis groups via CEUS to further group the non-sarcoidosis into tuberculosis, malignancy or inflammatory disorder. The percentage correction of prediction was 90% (18/20). CONCLUSION: NUS combined with CEUS has characteristic features in sarcoidosis with cervical lymph node involvement, which is helpful for its diagnosis and differential diagnosis. The binary classification model of NUS combined with CEUS features can help differentiate sarcoidosis from non-sarcoidosis groups. BioMed Central 2021-12-15 /pmc/articles/PMC8672511/ /pubmed/34911526 http://dx.doi.org/10.1186/s12890-021-01769-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Shen, Mengjun Zhou, Ying Gu, Weiqing Yin, Chengsheng Wang, Yin Zhang, Yuan Application of neck ultrasound in the diagnosis of sarcoidosis |
title | Application of neck ultrasound in the diagnosis of sarcoidosis |
title_full | Application of neck ultrasound in the diagnosis of sarcoidosis |
title_fullStr | Application of neck ultrasound in the diagnosis of sarcoidosis |
title_full_unstemmed | Application of neck ultrasound in the diagnosis of sarcoidosis |
title_short | Application of neck ultrasound in the diagnosis of sarcoidosis |
title_sort | application of neck ultrasound in the diagnosis of sarcoidosis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672511/ https://www.ncbi.nlm.nih.gov/pubmed/34911526 http://dx.doi.org/10.1186/s12890-021-01769-z |
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