STAT3 inhibitor mitigates cerebral amyloid angiopathy and parenchymal amyloid plaques while improving cognitive functions and brain networks

Previous reports indicate a potential role for signal transducer and activator of transcription 3 (STAT3) in amyloid-β (Aβ) processing and neuritic plaque pathogenesis. In the present study, the impact of STAT3 inhibition on cognition, cerebrovascular function, amyloid pathology, oxidative stress, a...

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Detalles Bibliográficos
Autores principales: Mehla, Jogender, Singh, Itender, Diwan, Deepti, Nelson, James W., Lawrence, Molly, Lee, Eunjae, Bauer, Adam Q., Holtzman, David M., Zipfel, Gregory J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672532/
https://www.ncbi.nlm.nih.gov/pubmed/34911575
http://dx.doi.org/10.1186/s40478-021-01293-5

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