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TBK1 recruitment to STING mediates autoinflammatory arthritis caused by defective DNA clearance
Defective DNA clearance in DNase II(−/−) mice leads to lethal inflammatory diseases that can be rescued by deleting cGAS or STING, but the role of distinct signaling pathways downstream of STING in the disease manifestation is not known. We found that the STING S365A mutation, which abrogates IRF3 b...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672646/ https://www.ncbi.nlm.nih.gov/pubmed/34901991 http://dx.doi.org/10.1084/jem.20211539 |