Engineered modular heterocyclic-diamidines for sequence-specific recognition of mixed AT/GC base pairs at the DNA minor groove

This report describes a breakthrough in a project to design minor groove binders to recognize any sequence of DNA. A key goal is to invent synthetic chemistry for compound preparation to recognize an adjacent GG sequence that has been difficult to target. After trying several unsuccessful compound d...

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Detalles Bibliográficos
Autores principales: Guo, Pu, Farahat, Abdelbasset A., Paul, Ananya, Boykin, David W., Wilson, W. David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672716/
https://www.ncbi.nlm.nih.gov/pubmed/35024109
http://dx.doi.org/10.1039/d1sc04720e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672716/
https://www.ncbi.nlm.nih.gov/pubmed/35024109
http://dx.doi.org/10.1039/d1sc04720e

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