Total synthesis and mechanism of action of the antibiotic armeniaspirol A

Emerging antimicrobial resistance urges the discovery of antibiotics with unexplored, resistance-breaking mechanisms. Armeniaspirols represent a novel class of antibiotics with a unique spiro[4.4]non-8-ene scaffold and potent activities against Gram-positive pathogens. We report a concise total synt...

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Detalles Bibliográficos
Autores principales: Arisetti, Nanaji, Fuchs, Hazel L. S., Coetzee, Janetta, Orozco, Manuel, Ruppelt, Dominik, Bauer, Armin, Heimann, Dominik, Kuhnert, Eric, Bhamidimarri, Satya P., Bafna, Jayesh A., Hinkelmann, Bettina, Eckel, Konstantin, Sieber, Stephan A., Müller, Peter P., Herrmann, Jennifer, Müller, Rolf, Winterhalter, Mathias, Steinem, Claudia, Brönstrup, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672772/
https://www.ncbi.nlm.nih.gov/pubmed/35024125
http://dx.doi.org/10.1039/d1sc04290d

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