Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging

Constitutive NF‐κB activation is associated with cellular senescence and stem cell dysfunction and rare variants in NF‐κB family members are enriched in centenarians. We recently identified a novel small molecule (SR12343) that inhibits IKK/NF‐κB activation by disrupting the association between IKKβ...

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Detalles Bibliográficos
Autores principales: Zhang, Lei, Zhao, Jing, Mu, Xiaodong, McGowan, Sara J., Angelini, Luise, O'Kelly, Ryan D., Yousefzadeh, Matthew J., Sakamoto, Ayumi, Aversa, Zaira, LeBrasseur, Nathan K., Suh, Yousin, Huard, Johnny, Kamenecka, Theodore M., Niedernhofer, Laura J., Robbins, Paul D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672781/
https://www.ncbi.nlm.nih.gov/pubmed/34734460
http://dx.doi.org/10.1111/acel.13486

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