Cargando…

α‐Synuclein antisense transcript SNCA‐AS1 regulates synapses‐ and aging‐related genes suggesting its implication in Parkinson's disease

SNCA protein product, α‐synuclein, is widely renowned for its role in synaptogenesis and implication in both aging and Parkinson's disease (PD), but research efforts are still needed to elucidate its physiological functions and mechanisms of regulation. In this work, we aim to characterize SNCA...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rey, Federica, Pandini, Cecilia, Messa, Letizia, Launi, Rossella, Barzaghini, Bianca, Zangaglia, Roberta, Raimondi, Manuela Teresa, Gagliardi, Stella, Cereda, Cristina, Zuccotti, Gian Vincenzo, Carelli, Stephana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672788/ https://www.ncbi.nlm.nih.gov/pubmed/34799977 http://dx.doi.org/10.1111/acel.13504

Ejemplares similares

Transcriptome Analysis of Subcutaneous Adipose Tissue from Severely Obese Patients Highlights Deregulation Profiles in Coding and Non-Coding Oncogenes
por: Rey, Federica, et al.
Publicado: (2021)

Neural Precursor Cells Expanded Inside the 3D Micro-Scaffold Nichoid Present Different Non-Coding RNAs Profiles and Transcript Isoforms Expression: Possible Epigenetic Modulation by 3D Growth
por: Messa, Letizia, et al.
Publicado: (2021)

Dissecting the Effect of a 3D Microscaffold on the Transcriptome of Neural Stem Cells with Computational Approaches: A Focus on Mechanotransduction
por: Rey, Federica, et al.
Publicado: (2020)

SNCA-AS1 in aging and Parkinson’s disease
por: Carelli, Stephana, et al.
Publicado: (2022)

RNA-seq dataset of subcutaneous adipose tissue: Transcriptional differences between obesity and healthy women
por: Messa, Letizia, et al.
Publicado: (2021)

RNA-seq Characterization of Sex-Differences in Adipose Tissue of Obesity Affected Patients: Computational Analysis of Differentially Expressed Coding and Non-Coding RNAs
por: Rey, Federica, et al.
Publicado: (2021)

Advances in Tissue Engineering and Innovative Fabrication Techniques for 3-D-Structures: Translational Applications in Neurodegenerative Diseases
por: Rey, Federica, et al.
Publicado: (2020)

Bone Marrow Mesenchymal Stem Cells Expanded Inside the Nichoid Micro-Scaffold: a Focus on Anti-Inflammatory Response
por: Barzaghini, Bianca, et al.
Publicado: (2023)

Neural precursors cells expanded in a 3D micro-engineered niche present enhanced therapeutic efficacy in vivo
por: Carelli, Stephana, et al.
Publicado: (2021)

3D photopolymerized microstructured scaffolds influence nuclear deformation, nucleo/cytoskeletal protein organization, and gene regulation in mesenchymal stem cells
por: Donnaloja, Francesca, et al.
Publicado: (2023)

Subcutaneous Adipose Tissue Transcriptome Highlights Specific Expression Profiles in Severe Pediatric Obesity: A Pilot Study
por: Berardo, Clarissa, et al.
Publicado: (2023)

Study of lncRNAs in Pediatric Neurological Diseases: Methods, Analysis of the State-of-Art and Possible Therapeutic Implications
por: Pandini, Cecilia, et al.
Publicado: (2023)

Biomaterials in Neurodegenerative Disorders: A Promising Therapeutic Approach
por: Bordoni, Matteo, et al.
Publicado: (2020)

Redox Imbalance in Neurological Disorders in Adults and Children
por: Rey, Federica, et al.
Publicado: (2023)

Alzheimer’s, Parkinson’s Disease and Amyotrophic Lateral Sclerosis Gene Expression Patterns Divergence Reveals Different Grade of RNA Metabolism Involvement
por: Garofalo, Maria, et al.
Publicado: (2020)

Bioengineering tools to speed up the discovery and preclinical testing of vaccines for SARS-CoV-2 and therapeutic agents for COVID-19
por: Raimondi, Manuela Teresa, et al.
Publicado: (2020)

Salivary total α-synuclein, oligomeric α-synuclein and SNCA variants in Parkinson’s disease patients
por: Kang, Wenyan, et al.
Publicado: (2016)

RNA Molecular Signature Profiling in PBMCs of Sporadic ALS Patients: HSP70 Overexpression Is Associated with Nuclear SOD1
por: Garofalo, Maria, et al.
Publicado: (2022)

LncRNAs Associated with Neuronal Development and Oncogenesis Are Deregulated in SOD1-G93A Murine Model of Amyotrophic Lateral Sclerosis
por: Rey, Federica, et al.
Publicado: (2021)

Genetic Variants of the α-Synuclein Gene SNCA Are Associated with Multiple System Atrophy
por: Al-Chalabi, Ammar, et al.
Publicado: (2009)

Snca-GFP Knock-In Mice Allows Tracking the Endogenous α-Synuclein in Action
por: Er, Safak
Publicado: (2021)

Mitochondrial dysfunctions in neurodegenerative diseases: role in disease pathogenesis, strategies for analysis and therapeutic prospects
por: Rey, Federica, et al.
Publicado: (2021)

The Length of SNCA Rep1 Microsatellite May Influence Cognitive Evolution in Parkinson’s Disease
por: Corrado, Lucia, et al.
Publicado: (2018)

A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity
por: Suresh, S. N., et al.
Publicado: (2017)

Network Analysis Implicates Alpha-Synuclein (Snca) in the Regulation of Ovariectomy-Induced Bone Loss
por: Calabrese, Gina, et al.
Publicado: (2016)

Targeted attenuation of elevated histone marks at SNCA alleviates α‐synuclein in Parkinson's disease
por: Guhathakurta, Subhrangshu, et al.
Publicado: (2021)

SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex
por: Brown, Jennifer L., et al.
Publicado: (2022)

New SNCA mutation and structures of α-synuclein filaments from juvenile-onset synucleinopathy
por: Yang, Yang, et al.
Publicado: (2023)

The Impact of SNCA Variations and Its Product Alpha-Synuclein on Non-Motor Features of Parkinson’s Disease
por: Magistrelli, Luca, et al.
Publicado: (2021)

Linking the phenotype of SNCA Triplication with PET-MRI imaging pattern and alpha-synuclein CSF seeding
por: Wurster, Isabel, et al.
Publicado: (2022)

Regulation of Αlpha-Synuclein Gene (SNCA) by Epigenetic Modifier TET1 in Parkinson Disease
por: Guhathakurta, Subhrangshu, et al.
Publicado: (2022)

Alpha‐synuclein mRNA isoform formation and translation affected by polymorphism in the human SNCA 3ʹUTR
por: Barrie, Elizabeth S., et al.
Publicado: (2018)

Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models
por: Prieto Huarcaya, Susy, et al.
Publicado: (2022)

From Neuronal Differentiation of iPSCs to 3D Neuro-Organoids: Modelling and Therapy of Neurodegenerative Diseases
por: Bordoni, Matteo, et al.
Publicado: (2018)

Modeling native and seeded Synuclein aggregation and related cellular dysfunctions in dopaminergic neurons derived by a new set of isogenic iPSC lines with SNCA multiplications
por: Iannielli, Angelo, et al.
Publicado: (2022)

Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies
por: Bras, Jose, et al.
Publicado: (2014)

Patients’ Stem Cells Differentiation in a 3D Environment as a Promising Experimental Tool for the Study of Amyotrophic Lateral Sclerosis
por: Scarian, Eveljn, et al.
Publicado: (2022)

Role of long non‐coding RNAs in adipogenesis: State of the art and implications in obesity and obesity‐associated diseases
por: Rey, Federica, et al.
Publicado: (2021)

The SNCA-Rep1 Polymorphic Locus: Association with the Risk of Parkinson’s Disease and SNCA Gene Methylation
por: Iakovenko, E. V., et al.
Publicado: (2020)

Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human α-synuclein in transgenic mouse brain
por: Cronin, Kenneth D., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_jimklmr87tta5tjtu97t5mtr7n