In Vitro Evaluation of the Activity of Aztreonam-Avibactam against 341 Recent Clinical Isolates of Anaerobes

Aztreonam-avibactam is under clinical development for multidrug-resistant Gram-negative infections. We evaluated in vitro activity against 341 recent clinical isolates. The addition of avibactam to aztreonam had no effect on the anaerobic activity of aztreonam. IMPORTANCE This work shows that aztreo...

Descripción completa

Detalles Bibliográficos
Autores principales: Snydman, David R., McDermott, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Observation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672875/
https://www.ncbi.nlm.nih.gov/pubmed/34908432
http://dx.doi.org/10.1128/Spectrum.01908-21
_version_ 1784615429866520576
author Snydman, David R.
McDermott, Laura
author_facet Snydman, David R.
McDermott, Laura
author_sort Snydman, David R.
collection PubMed
description Aztreonam-avibactam is under clinical development for multidrug-resistant Gram-negative infections. We evaluated in vitro activity against 341 recent clinical isolates. The addition of avibactam to aztreonam had no effect on the anaerobic activity of aztreonam. IMPORTANCE This work shows that aztreonam-avibactam lacks activity against anaerobic organisms.
format Online
Article
Text
id pubmed-8672875
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher American Society for Microbiology
record_format MEDLINE/PubMed
spelling pubmed-86728752021-12-16 In Vitro Evaluation of the Activity of Aztreonam-Avibactam against 341 Recent Clinical Isolates of Anaerobes Snydman, David R. McDermott, Laura Microbiol Spectr Observation Aztreonam-avibactam is under clinical development for multidrug-resistant Gram-negative infections. We evaluated in vitro activity against 341 recent clinical isolates. The addition of avibactam to aztreonam had no effect on the anaerobic activity of aztreonam. IMPORTANCE This work shows that aztreonam-avibactam lacks activity against anaerobic organisms. American Society for Microbiology 2021-12-15 /pmc/articles/PMC8672875/ /pubmed/34908432 http://dx.doi.org/10.1128/Spectrum.01908-21 Text en Copyright © 2021 Snydman and McDermott. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Observation
Snydman, David R.
McDermott, Laura
In Vitro Evaluation of the Activity of Aztreonam-Avibactam against 341 Recent Clinical Isolates of Anaerobes
title In Vitro Evaluation of the Activity of Aztreonam-Avibactam against 341 Recent Clinical Isolates of Anaerobes
title_full In Vitro Evaluation of the Activity of Aztreonam-Avibactam against 341 Recent Clinical Isolates of Anaerobes
title_fullStr In Vitro Evaluation of the Activity of Aztreonam-Avibactam against 341 Recent Clinical Isolates of Anaerobes
title_full_unstemmed In Vitro Evaluation of the Activity of Aztreonam-Avibactam against 341 Recent Clinical Isolates of Anaerobes
title_short In Vitro Evaluation of the Activity of Aztreonam-Avibactam against 341 Recent Clinical Isolates of Anaerobes
title_sort in vitro evaluation of the activity of aztreonam-avibactam against 341 recent clinical isolates of anaerobes
topic Observation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672875/
https://www.ncbi.nlm.nih.gov/pubmed/34908432
http://dx.doi.org/10.1128/Spectrum.01908-21
work_keys_str_mv AT snydmandavidr invitroevaluationoftheactivityofaztreonamavibactamagainst341recentclinicalisolatesofanaerobes
AT mcdermottlaura invitroevaluationoftheactivityofaztreonamavibactamagainst341recentclinicalisolatesofanaerobes

Ejemplares similares