Cargando…
Dynamic changes in practical inflammation and immunity markers in cancer patients receiving immune-enhancing nutritional supplementation during concurrent chemoradiotherapy
BACKGROUND: Immune-enhancing nutrition (IMN) strengthens the systematic inflammatory response and the immune system. Neutrophil to lymphocyte ratio (NLR) and absolute lymphocyte count (ALC) are affected during cancer therapies. OBJECTIVE: We carried out an analysis of the dynamic changes in NLR and...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673492/ https://www.ncbi.nlm.nih.gov/pubmed/34151843 http://dx.doi.org/10.3233/CBM-210086 |
_version_ | 1784615462193070080 |
---|---|
author | Homkham, Nontiya Muangwong, Pooriwat Pisprasert, Veeradej Traisathit, Patrinee Jiratrachu, Rungarun Chottaweesak, Pattawee Chitapanarux, Imjai |
author_facet | Homkham, Nontiya Muangwong, Pooriwat Pisprasert, Veeradej Traisathit, Patrinee Jiratrachu, Rungarun Chottaweesak, Pattawee Chitapanarux, Imjai |
author_sort | Homkham, Nontiya |
collection | PubMed |
description | BACKGROUND: Immune-enhancing nutrition (IMN) strengthens the systematic inflammatory response and the immune system. Neutrophil to lymphocyte ratio (NLR) and absolute lymphocyte count (ALC) are affected during cancer therapies. OBJECTIVE: We carried out an analysis of the dynamic changes in NLR and ALC over time in cancer patients with or without IMN supplementation. METHODS: 88 cancer patients receiving concurrent chemoradiotherapy (CCRT) were randomized into regular diet group, and regular diet and IMN group.Generalized estimation equation models were used to assess associations between patient’s characteristics, IMN, and dynamic changes in NLR and ALC over time. RESULTS: NLR and ALC at pre-CCRT were significantly associated with dynamic changes in NLR (adjusted [Formula: see text] 1.08, 95% confidence interval [CI]: 0.64–1.52) and ALC (adjusted [Formula: see text] 0.41, 95% CI: 0.36–0.46). The magnitudes of the NLR and ALC changes through CCRT were lower in patients receiving IMN, although the differences were not statistically significant except ALC at the end of CCRT in head and neck cancer patients ([Formula: see text] 0.023). CONCLUSION: Dynamic negative changes in both markers were demonstrated throughout CCRT. There were non-significant trend in promising changes in both NLR and ALC values in the whole group in IMN supplementation. |
format | Online Article Text |
id | pubmed-8673492 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-86734922021-12-29 Dynamic changes in practical inflammation and immunity markers in cancer patients receiving immune-enhancing nutritional supplementation during concurrent chemoradiotherapy Homkham, Nontiya Muangwong, Pooriwat Pisprasert, Veeradej Traisathit, Patrinee Jiratrachu, Rungarun Chottaweesak, Pattawee Chitapanarux, Imjai Cancer Biomark Research Article BACKGROUND: Immune-enhancing nutrition (IMN) strengthens the systematic inflammatory response and the immune system. Neutrophil to lymphocyte ratio (NLR) and absolute lymphocyte count (ALC) are affected during cancer therapies. OBJECTIVE: We carried out an analysis of the dynamic changes in NLR and ALC over time in cancer patients with or without IMN supplementation. METHODS: 88 cancer patients receiving concurrent chemoradiotherapy (CCRT) were randomized into regular diet group, and regular diet and IMN group.Generalized estimation equation models were used to assess associations between patient’s characteristics, IMN, and dynamic changes in NLR and ALC over time. RESULTS: NLR and ALC at pre-CCRT were significantly associated with dynamic changes in NLR (adjusted [Formula: see text] 1.08, 95% confidence interval [CI]: 0.64–1.52) and ALC (adjusted [Formula: see text] 0.41, 95% CI: 0.36–0.46). The magnitudes of the NLR and ALC changes through CCRT were lower in patients receiving IMN, although the differences were not statistically significant except ALC at the end of CCRT in head and neck cancer patients ([Formula: see text] 0.023). CONCLUSION: Dynamic negative changes in both markers were demonstrated throughout CCRT. There were non-significant trend in promising changes in both NLR and ALC values in the whole group in IMN supplementation. IOS Press 2021-11-10 /pmc/articles/PMC8673492/ /pubmed/34151843 http://dx.doi.org/10.3233/CBM-210086 Text en © 2021 – The authors. Published by IOS Press. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Homkham, Nontiya Muangwong, Pooriwat Pisprasert, Veeradej Traisathit, Patrinee Jiratrachu, Rungarun Chottaweesak, Pattawee Chitapanarux, Imjai Dynamic changes in practical inflammation and immunity markers in cancer patients receiving immune-enhancing nutritional supplementation during concurrent chemoradiotherapy |
title | Dynamic changes in practical inflammation and immunity markers in cancer patients receiving immune-enhancing nutritional supplementation during concurrent chemoradiotherapy |
title_full | Dynamic changes in practical inflammation and immunity markers in cancer patients receiving immune-enhancing nutritional supplementation during concurrent chemoradiotherapy |
title_fullStr | Dynamic changes in practical inflammation and immunity markers in cancer patients receiving immune-enhancing nutritional supplementation during concurrent chemoradiotherapy |
title_full_unstemmed | Dynamic changes in practical inflammation and immunity markers in cancer patients receiving immune-enhancing nutritional supplementation during concurrent chemoradiotherapy |
title_short | Dynamic changes in practical inflammation and immunity markers in cancer patients receiving immune-enhancing nutritional supplementation during concurrent chemoradiotherapy |
title_sort | dynamic changes in practical inflammation and immunity markers in cancer patients receiving immune-enhancing nutritional supplementation during concurrent chemoradiotherapy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673492/ https://www.ncbi.nlm.nih.gov/pubmed/34151843 http://dx.doi.org/10.3233/CBM-210086 |
work_keys_str_mv | AT homkhamnontiya dynamicchangesinpracticalinflammationandimmunitymarkersincancerpatientsreceivingimmuneenhancingnutritionalsupplementationduringconcurrentchemoradiotherapy AT muangwongpooriwat dynamicchangesinpracticalinflammationandimmunitymarkersincancerpatientsreceivingimmuneenhancingnutritionalsupplementationduringconcurrentchemoradiotherapy AT pisprasertveeradej dynamicchangesinpracticalinflammationandimmunitymarkersincancerpatientsreceivingimmuneenhancingnutritionalsupplementationduringconcurrentchemoradiotherapy AT traisathitpatrinee dynamicchangesinpracticalinflammationandimmunitymarkersincancerpatientsreceivingimmuneenhancingnutritionalsupplementationduringconcurrentchemoradiotherapy AT jiratrachurungarun dynamicchangesinpracticalinflammationandimmunitymarkersincancerpatientsreceivingimmuneenhancingnutritionalsupplementationduringconcurrentchemoradiotherapy AT chottaweesakpattawee dynamicchangesinpracticalinflammationandimmunitymarkersincancerpatientsreceivingimmuneenhancingnutritionalsupplementationduringconcurrentchemoradiotherapy AT chitapanaruximjai dynamicchangesinpracticalinflammationandimmunitymarkersincancerpatientsreceivingimmuneenhancingnutritionalsupplementationduringconcurrentchemoradiotherapy |