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Dynamic changes in practical inflammation and immunity markers in cancer patients receiving immune-enhancing nutritional supplementation during concurrent chemoradiotherapy

BACKGROUND: Immune-enhancing nutrition (IMN) strengthens the systematic inflammatory response and the immune system. Neutrophil to lymphocyte ratio (NLR) and absolute lymphocyte count (ALC) are affected during cancer therapies. OBJECTIVE: We carried out an analysis of the dynamic changes in NLR and...

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Autores principales: Homkham, Nontiya, Muangwong, Pooriwat, Pisprasert, Veeradej, Traisathit, Patrinee, Jiratrachu, Rungarun, Chottaweesak, Pattawee, Chitapanarux, Imjai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673492/
https://www.ncbi.nlm.nih.gov/pubmed/34151843
http://dx.doi.org/10.3233/CBM-210086
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author Homkham, Nontiya
Muangwong, Pooriwat
Pisprasert, Veeradej
Traisathit, Patrinee
Jiratrachu, Rungarun
Chottaweesak, Pattawee
Chitapanarux, Imjai
author_facet Homkham, Nontiya
Muangwong, Pooriwat
Pisprasert, Veeradej
Traisathit, Patrinee
Jiratrachu, Rungarun
Chottaweesak, Pattawee
Chitapanarux, Imjai
author_sort Homkham, Nontiya
collection PubMed
description BACKGROUND: Immune-enhancing nutrition (IMN) strengthens the systematic inflammatory response and the immune system. Neutrophil to lymphocyte ratio (NLR) and absolute lymphocyte count (ALC) are affected during cancer therapies. OBJECTIVE: We carried out an analysis of the dynamic changes in NLR and ALC over time in cancer patients with or without IMN supplementation. METHODS: 88 cancer patients receiving concurrent chemoradiotherapy (CCRT) were randomized into regular diet group, and regular diet and IMN group.Generalized estimation equation models were used to assess associations between patient’s characteristics, IMN, and dynamic changes in NLR and ALC over time. RESULTS: NLR and ALC at pre-CCRT were significantly associated with dynamic changes in NLR (adjusted [Formula: see text] 1.08, 95% confidence interval [CI]: 0.64–1.52) and ALC (adjusted [Formula: see text] 0.41, 95% CI: 0.36–0.46). The magnitudes of the NLR and ALC changes through CCRT were lower in patients receiving IMN, although the differences were not statistically significant except ALC at the end of CCRT in head and neck cancer patients ([Formula: see text] 0.023). CONCLUSION: Dynamic negative changes in both markers were demonstrated throughout CCRT. There were non-significant trend in promising changes in both NLR and ALC values in the whole group in IMN supplementation.
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spelling pubmed-86734922021-12-29 Dynamic changes in practical inflammation and immunity markers in cancer patients receiving immune-enhancing nutritional supplementation during concurrent chemoradiotherapy Homkham, Nontiya Muangwong, Pooriwat Pisprasert, Veeradej Traisathit, Patrinee Jiratrachu, Rungarun Chottaweesak, Pattawee Chitapanarux, Imjai Cancer Biomark Research Article BACKGROUND: Immune-enhancing nutrition (IMN) strengthens the systematic inflammatory response and the immune system. Neutrophil to lymphocyte ratio (NLR) and absolute lymphocyte count (ALC) are affected during cancer therapies. OBJECTIVE: We carried out an analysis of the dynamic changes in NLR and ALC over time in cancer patients with or without IMN supplementation. METHODS: 88 cancer patients receiving concurrent chemoradiotherapy (CCRT) were randomized into regular diet group, and regular diet and IMN group.Generalized estimation equation models were used to assess associations between patient’s characteristics, IMN, and dynamic changes in NLR and ALC over time. RESULTS: NLR and ALC at pre-CCRT were significantly associated with dynamic changes in NLR (adjusted [Formula: see text] 1.08, 95% confidence interval [CI]: 0.64–1.52) and ALC (adjusted [Formula: see text] 0.41, 95% CI: 0.36–0.46). The magnitudes of the NLR and ALC changes through CCRT were lower in patients receiving IMN, although the differences were not statistically significant except ALC at the end of CCRT in head and neck cancer patients ([Formula: see text] 0.023). CONCLUSION: Dynamic negative changes in both markers were demonstrated throughout CCRT. There were non-significant trend in promising changes in both NLR and ALC values in the whole group in IMN supplementation. IOS Press 2021-11-10 /pmc/articles/PMC8673492/ /pubmed/34151843 http://dx.doi.org/10.3233/CBM-210086 Text en © 2021 – The authors. Published by IOS Press. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Homkham, Nontiya
Muangwong, Pooriwat
Pisprasert, Veeradej
Traisathit, Patrinee
Jiratrachu, Rungarun
Chottaweesak, Pattawee
Chitapanarux, Imjai
Dynamic changes in practical inflammation and immunity markers in cancer patients receiving immune-enhancing nutritional supplementation during concurrent chemoradiotherapy
title Dynamic changes in practical inflammation and immunity markers in cancer patients receiving immune-enhancing nutritional supplementation during concurrent chemoradiotherapy
title_full Dynamic changes in practical inflammation and immunity markers in cancer patients receiving immune-enhancing nutritional supplementation during concurrent chemoradiotherapy
title_fullStr Dynamic changes in practical inflammation and immunity markers in cancer patients receiving immune-enhancing nutritional supplementation during concurrent chemoradiotherapy
title_full_unstemmed Dynamic changes in practical inflammation and immunity markers in cancer patients receiving immune-enhancing nutritional supplementation during concurrent chemoradiotherapy
title_short Dynamic changes in practical inflammation and immunity markers in cancer patients receiving immune-enhancing nutritional supplementation during concurrent chemoradiotherapy
title_sort dynamic changes in practical inflammation and immunity markers in cancer patients receiving immune-enhancing nutritional supplementation during concurrent chemoradiotherapy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673492/
https://www.ncbi.nlm.nih.gov/pubmed/34151843
http://dx.doi.org/10.3233/CBM-210086
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