Cargando…
Recurring Gastrointestinal Infections Increase the Risk of Dementia
BACKGROUND: Gastrointestinal infections cause significant health problems, including those affecting the immune, musculoskeletal, and nervous system, and are one of the leading causes for death worldwide. Recent findings suggest that microbiota of the gastrointestinal tract contribute to dementia. O...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673498/ https://www.ncbi.nlm.nih.gov/pubmed/34602468 http://dx.doi.org/10.3233/JAD-210316 |
_version_ | 1784615463596064768 |
---|---|
author | Fink, Anne Doblhammer, Gabriele Tamgüney, Gültekin |
author_facet | Fink, Anne Doblhammer, Gabriele Tamgüney, Gültekin |
author_sort | Fink, Anne |
collection | PubMed |
description | BACKGROUND: Gastrointestinal infections cause significant health problems, including those affecting the immune, musculoskeletal, and nervous system, and are one of the leading causes for death worldwide. Recent findings suggest that microbiota of the gastrointestinal tract contribute to dementia. OBJECTIVE: In this nested case-control study we investigated the role of common gastrointestinal infections on the subsequent risk of dementia. METHODS: We used a longitudinal sample of 202,806 individuals from health claims data of the largest German health insurer and applied a nested case-control design with 23,354 initial dementia cases between 2006 and 2014 and 23,354 matched controls. We used conditional logistic regression to compute odds ratios (ORs) for dementia and corresponding 95%confidence intervals (CIs), adjusting for potential confounders. RESULTS: The risk of dementia was increased in patients with recurring incidences of quarters with diagnosed gastrointestinal infections when compared to the unexposed population (one quarter: OR = 1.49, 95%CI = 1.40–1.58; two quarters: OR = 1.70, 95%CI = 1.51–1.91; three or more quarters: OR = 1.64, 95%CI = 1.40–1.93), adjusted for potential confounders. CONCLUSION: Our findings suggest that recurring gastrointestinal infections are associated with an increased risk of subsequent dementia. |
format | Online Article Text |
id | pubmed-8673498 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-86734982021-12-29 Recurring Gastrointestinal Infections Increase the Risk of Dementia Fink, Anne Doblhammer, Gabriele Tamgüney, Gültekin J Alzheimers Dis Research Article BACKGROUND: Gastrointestinal infections cause significant health problems, including those affecting the immune, musculoskeletal, and nervous system, and are one of the leading causes for death worldwide. Recent findings suggest that microbiota of the gastrointestinal tract contribute to dementia. OBJECTIVE: In this nested case-control study we investigated the role of common gastrointestinal infections on the subsequent risk of dementia. METHODS: We used a longitudinal sample of 202,806 individuals from health claims data of the largest German health insurer and applied a nested case-control design with 23,354 initial dementia cases between 2006 and 2014 and 23,354 matched controls. We used conditional logistic regression to compute odds ratios (ORs) for dementia and corresponding 95%confidence intervals (CIs), adjusting for potential confounders. RESULTS: The risk of dementia was increased in patients with recurring incidences of quarters with diagnosed gastrointestinal infections when compared to the unexposed population (one quarter: OR = 1.49, 95%CI = 1.40–1.58; two quarters: OR = 1.70, 95%CI = 1.51–1.91; three or more quarters: OR = 1.64, 95%CI = 1.40–1.93), adjusted for potential confounders. CONCLUSION: Our findings suggest that recurring gastrointestinal infections are associated with an increased risk of subsequent dementia. IOS Press 2021-11-09 /pmc/articles/PMC8673498/ /pubmed/34602468 http://dx.doi.org/10.3233/JAD-210316 Text en © 2021 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Fink, Anne Doblhammer, Gabriele Tamgüney, Gültekin Recurring Gastrointestinal Infections Increase the Risk of Dementia |
title | Recurring Gastrointestinal Infections Increase the Risk of Dementia |
title_full | Recurring Gastrointestinal Infections Increase the Risk of Dementia |
title_fullStr | Recurring Gastrointestinal Infections Increase the Risk of Dementia |
title_full_unstemmed | Recurring Gastrointestinal Infections Increase the Risk of Dementia |
title_short | Recurring Gastrointestinal Infections Increase the Risk of Dementia |
title_sort | recurring gastrointestinal infections increase the risk of dementia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673498/ https://www.ncbi.nlm.nih.gov/pubmed/34602468 http://dx.doi.org/10.3233/JAD-210316 |
work_keys_str_mv | AT finkanne recurringgastrointestinalinfectionsincreasetheriskofdementia AT doblhammergabriele recurringgastrointestinalinfectionsincreasetheriskofdementia AT tamguneygultekin recurringgastrointestinalinfectionsincreasetheriskofdementia |