A Multi-Omic Huntington’s Disease Transgenic Sheep-Model Database for Investigating Disease Pathogenesis

BACKGROUND: The pathological mechanism of cellular dysfunction and death in Huntington’s disease (HD) is not well defined. Our transgenic HD sheep model (OVT73) was generated to investigate these mechanisms and for therapeutic testing. One particular cohort of animals has undergone focused investiga...

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Detalles Bibliográficos
Autores principales: Mears, Emily R., Handley, Renee R., Grant, Matthew J., Reid, Suzanne J., Day, Benjamin T., Rudiger, Skye R., McLaughlan, Clive J., Verma, Paul J., Bawden, Simon C., Patassini, Stefano, Unwin, Richard D., Cooper, Garth J.S., Gusella, James F., MacDonald, Marcy E., Brauning, Rudiger, Maclean, Paul, Pearson, John F., Waldvogel, Henry J., Faull, Richard L.M., Snell, Russell G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2021
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673501/
https://www.ncbi.nlm.nih.gov/pubmed/34420978
http://dx.doi.org/10.3233/JHD-210482

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