A Cystatin C Cleavage ELISA Assay as a Quality Control Tool for Determining Sub-Optimal Storage Conditions of Cerebrospinal Fluid Samples in Alzheimer’s Disease Research

BACKGROUND: An N-terminal octapeptide cleavage of the cystatin C protein was discovered by mass spectrometry when cerebrospinal fluid (CSF) was stored at –20°C for 3 months, which did not occur when CSF was stored at –80°C. OBJECTIVE: The aim was to develop an immunoassay as quality assessment tool...

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Detalles Bibliográficos
Autores principales: Mommaerts, Kathleen, Willemse, Eline A.J., Marchese, Monica, Larue, Catherine, van der Flier, Wiesje M., Betsou, Fay, Teunissen, Charlotte E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673510/
https://www.ncbi.nlm.nih.gov/pubmed/34420976
http://dx.doi.org/10.3233/JAD-210741

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