Fusion transcripts and their genomic breakpoints in polyadenylated and ribosomal RNA–minus RNA sequencing data

BACKGROUND: Fusion genes are typically identified by RNA sequencing (RNA-seq) without elucidating the causal genomic breakpoints. However, non–poly(A)-enriched RNA-seq contains large proportions of intronic reads that also span genomic breakpoints. RESULTS: We have developed an algorithm, Dr. Disco,...

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Detalles Bibliográficos
Autores principales: Hoogstrate, Youri, Komor, Malgorzata A, Böttcher, René, van Riet, Job, van de Werken, Harmen J G, van Lieshout, Stef, Hoffmann, Ralf, van den Broek, Evert, Bolijn, Anne S, Dits, Natasja, Sie, Daoud, van der Meer, David, Pepers, Floor, Bangma, Chris H, van Leenders, Geert J L H, Smid, Marcel, French, Pim J, Martens, John W M, van Workum, Wilbert, van der Spek, Peter J, Janssen, Bart, Caldenhoven, Eric, Rausch, Christian, de Jong, Mark, Stubbs, Andrew P, Meijer, Gerrit A, Fijneman, Remond J A, Jenster, Guido W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Technical Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673554/
https://www.ncbi.nlm.nih.gov/pubmed/34891161
http://dx.doi.org/10.1093/gigascience/giab080

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