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On Hallucinations in Tomographic Image Reconstruction

Tomographic image reconstruction is generally an ill-posed linear inverse problem. Such ill-posed inverse problems are typically regularized using prior knowledge of the sought-after object property. Recently, deep neural networks have been actively investigated for regularizing image reconstruction...

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Autores principales: Bhadra, Sayantan, Kelkar, Varun A., Brooks, Frank J., Anastasio, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673588/
https://www.ncbi.nlm.nih.gov/pubmed/33950837
http://dx.doi.org/10.1109/TMI.2021.3077857
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author Bhadra, Sayantan
Kelkar, Varun A.
Brooks, Frank J.
Anastasio, Mark A.
author_facet Bhadra, Sayantan
Kelkar, Varun A.
Brooks, Frank J.
Anastasio, Mark A.
author_sort Bhadra, Sayantan
collection PubMed
description Tomographic image reconstruction is generally an ill-posed linear inverse problem. Such ill-posed inverse problems are typically regularized using prior knowledge of the sought-after object property. Recently, deep neural networks have been actively investigated for regularizing image reconstruction problems by learning a prior for the object properties from training images. However, an analysis of the prior information learned by these deep networks and their ability to generalize to data that may lie outside the training distribution is still being explored. An inaccurate prior might lead to false structures being hallucinated in the reconstructed image and that is a cause for serious concern in medical imaging. In this work, we propose to illustrate the effect of the prior imposed by a reconstruction method by decomposing the image estimate into generalized measurement and null components. The concept of a hallucination map is introduced for the general purpose of understanding the effect of the prior in regularized reconstruction methods. Numerical studies are conducted corresponding to a stylized tomographic imaging modality. The behavior of different reconstruction methods under the proposed formalism is discussed with the help of the numerical studies.
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spelling pubmed-86735882021-12-15 On Hallucinations in Tomographic Image Reconstruction Bhadra, Sayantan Kelkar, Varun A. Brooks, Frank J. Anastasio, Mark A. IEEE Trans Med Imaging Article Tomographic image reconstruction is generally an ill-posed linear inverse problem. Such ill-posed inverse problems are typically regularized using prior knowledge of the sought-after object property. Recently, deep neural networks have been actively investigated for regularizing image reconstruction problems by learning a prior for the object properties from training images. However, an analysis of the prior information learned by these deep networks and their ability to generalize to data that may lie outside the training distribution is still being explored. An inaccurate prior might lead to false structures being hallucinated in the reconstructed image and that is a cause for serious concern in medical imaging. In this work, we propose to illustrate the effect of the prior imposed by a reconstruction method by decomposing the image estimate into generalized measurement and null components. The concept of a hallucination map is introduced for the general purpose of understanding the effect of the prior in regularized reconstruction methods. Numerical studies are conducted corresponding to a stylized tomographic imaging modality. The behavior of different reconstruction methods under the proposed formalism is discussed with the help of the numerical studies. 2021-10-27 2021-11 /pmc/articles/PMC8673588/ /pubmed/33950837 http://dx.doi.org/10.1109/TMI.2021.3077857 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 License. For more information, see https://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Bhadra, Sayantan
Kelkar, Varun A.
Brooks, Frank J.
Anastasio, Mark A.
On Hallucinations in Tomographic Image Reconstruction
title On Hallucinations in Tomographic Image Reconstruction
title_full On Hallucinations in Tomographic Image Reconstruction
title_fullStr On Hallucinations in Tomographic Image Reconstruction
title_full_unstemmed On Hallucinations in Tomographic Image Reconstruction
title_short On Hallucinations in Tomographic Image Reconstruction
title_sort on hallucinations in tomographic image reconstruction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673588/
https://www.ncbi.nlm.nih.gov/pubmed/33950837
http://dx.doi.org/10.1109/TMI.2021.3077857
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