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On Hallucinations in Tomographic Image Reconstruction
Tomographic image reconstruction is generally an ill-posed linear inverse problem. Such ill-posed inverse problems are typically regularized using prior knowledge of the sought-after object property. Recently, deep neural networks have been actively investigated for regularizing image reconstruction...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673588/ https://www.ncbi.nlm.nih.gov/pubmed/33950837 http://dx.doi.org/10.1109/TMI.2021.3077857 |
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author | Bhadra, Sayantan Kelkar, Varun A. Brooks, Frank J. Anastasio, Mark A. |
author_facet | Bhadra, Sayantan Kelkar, Varun A. Brooks, Frank J. Anastasio, Mark A. |
author_sort | Bhadra, Sayantan |
collection | PubMed |
description | Tomographic image reconstruction is generally an ill-posed linear inverse problem. Such ill-posed inverse problems are typically regularized using prior knowledge of the sought-after object property. Recently, deep neural networks have been actively investigated for regularizing image reconstruction problems by learning a prior for the object properties from training images. However, an analysis of the prior information learned by these deep networks and their ability to generalize to data that may lie outside the training distribution is still being explored. An inaccurate prior might lead to false structures being hallucinated in the reconstructed image and that is a cause for serious concern in medical imaging. In this work, we propose to illustrate the effect of the prior imposed by a reconstruction method by decomposing the image estimate into generalized measurement and null components. The concept of a hallucination map is introduced for the general purpose of understanding the effect of the prior in regularized reconstruction methods. Numerical studies are conducted corresponding to a stylized tomographic imaging modality. The behavior of different reconstruction methods under the proposed formalism is discussed with the help of the numerical studies. |
format | Online Article Text |
id | pubmed-8673588 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
record_format | MEDLINE/PubMed |
spelling | pubmed-86735882021-12-15 On Hallucinations in Tomographic Image Reconstruction Bhadra, Sayantan Kelkar, Varun A. Brooks, Frank J. Anastasio, Mark A. IEEE Trans Med Imaging Article Tomographic image reconstruction is generally an ill-posed linear inverse problem. Such ill-posed inverse problems are typically regularized using prior knowledge of the sought-after object property. Recently, deep neural networks have been actively investigated for regularizing image reconstruction problems by learning a prior for the object properties from training images. However, an analysis of the prior information learned by these deep networks and their ability to generalize to data that may lie outside the training distribution is still being explored. An inaccurate prior might lead to false structures being hallucinated in the reconstructed image and that is a cause for serious concern in medical imaging. In this work, we propose to illustrate the effect of the prior imposed by a reconstruction method by decomposing the image estimate into generalized measurement and null components. The concept of a hallucination map is introduced for the general purpose of understanding the effect of the prior in regularized reconstruction methods. Numerical studies are conducted corresponding to a stylized tomographic imaging modality. The behavior of different reconstruction methods under the proposed formalism is discussed with the help of the numerical studies. 2021-10-27 2021-11 /pmc/articles/PMC8673588/ /pubmed/33950837 http://dx.doi.org/10.1109/TMI.2021.3077857 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 License. For more information, see https://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Bhadra, Sayantan Kelkar, Varun A. Brooks, Frank J. Anastasio, Mark A. On Hallucinations in Tomographic Image Reconstruction |
title | On Hallucinations in Tomographic Image Reconstruction |
title_full | On Hallucinations in Tomographic Image Reconstruction |
title_fullStr | On Hallucinations in Tomographic Image Reconstruction |
title_full_unstemmed | On Hallucinations in Tomographic Image Reconstruction |
title_short | On Hallucinations in Tomographic Image Reconstruction |
title_sort | on hallucinations in tomographic image reconstruction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673588/ https://www.ncbi.nlm.nih.gov/pubmed/33950837 http://dx.doi.org/10.1109/TMI.2021.3077857 |
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