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Early Hyporegenerative Anemia Complicating Hemolytic Disease of the Newborn Secondary to Rhesus Alloimmunization
Rhesus hemolytic disease of the newborn is rarely found after the implementation of anti-D immunoglobulin prophylaxis. However, it may lead to cholestasis, elevated liver transaminases, hyperbilirubinemia, kernicterus, iron overload, and hyporegenerative anemia. Hyporegenerative anemia is characteri...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673681/ https://www.ncbi.nlm.nih.gov/pubmed/34926072 http://dx.doi.org/10.7759/cureus.19603 |
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author | Acosta, Catalina Idris, Isra Romero, Rossana Ablan, Lilian Montoya Novoa, Armyda Abdalaziz, Awadelkarim Rodriguez, Alexander |
author_facet | Acosta, Catalina Idris, Isra Romero, Rossana Ablan, Lilian Montoya Novoa, Armyda Abdalaziz, Awadelkarim Rodriguez, Alexander |
author_sort | Acosta, Catalina |
collection | PubMed |
description | Rhesus hemolytic disease of the newborn is rarely found after the implementation of anti-D immunoglobulin prophylaxis. However, it may lead to cholestasis, elevated liver transaminases, hyperbilirubinemia, kernicterus, iron overload, and hyporegenerative anemia. Hyporegenerative anemia is characterized by low hemoglobin and reticulocyte count. It is typically recognized two to six weeks after birth. The etiology of this type of anemia is not identified yet, and treatment is controversial. We report a case of a neonate with rhesus hemolytic disease of the newborn with early hyporegenerative anemia that was noted on day seven of life. The available literature has described a similar age of onset, but after two weeks of life and not as early as on day seven of life as in our case. We treated this type of anemia with the standard of care management that includes phototherapy, intravenous immunoglobulin, and blood transfusions. |
format | Online Article Text |
id | pubmed-8673681 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-86736812021-12-16 Early Hyporegenerative Anemia Complicating Hemolytic Disease of the Newborn Secondary to Rhesus Alloimmunization Acosta, Catalina Idris, Isra Romero, Rossana Ablan, Lilian Montoya Novoa, Armyda Abdalaziz, Awadelkarim Rodriguez, Alexander Cureus Pediatrics Rhesus hemolytic disease of the newborn is rarely found after the implementation of anti-D immunoglobulin prophylaxis. However, it may lead to cholestasis, elevated liver transaminases, hyperbilirubinemia, kernicterus, iron overload, and hyporegenerative anemia. Hyporegenerative anemia is characterized by low hemoglobin and reticulocyte count. It is typically recognized two to six weeks after birth. The etiology of this type of anemia is not identified yet, and treatment is controversial. We report a case of a neonate with rhesus hemolytic disease of the newborn with early hyporegenerative anemia that was noted on day seven of life. The available literature has described a similar age of onset, but after two weeks of life and not as early as on day seven of life as in our case. We treated this type of anemia with the standard of care management that includes phototherapy, intravenous immunoglobulin, and blood transfusions. Cureus 2021-11-15 /pmc/articles/PMC8673681/ /pubmed/34926072 http://dx.doi.org/10.7759/cureus.19603 Text en Copyright © 2021, Acosta et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Pediatrics Acosta, Catalina Idris, Isra Romero, Rossana Ablan, Lilian Montoya Novoa, Armyda Abdalaziz, Awadelkarim Rodriguez, Alexander Early Hyporegenerative Anemia Complicating Hemolytic Disease of the Newborn Secondary to Rhesus Alloimmunization |
title | Early Hyporegenerative Anemia Complicating Hemolytic Disease of the Newborn Secondary to Rhesus Alloimmunization |
title_full | Early Hyporegenerative Anemia Complicating Hemolytic Disease of the Newborn Secondary to Rhesus Alloimmunization |
title_fullStr | Early Hyporegenerative Anemia Complicating Hemolytic Disease of the Newborn Secondary to Rhesus Alloimmunization |
title_full_unstemmed | Early Hyporegenerative Anemia Complicating Hemolytic Disease of the Newborn Secondary to Rhesus Alloimmunization |
title_short | Early Hyporegenerative Anemia Complicating Hemolytic Disease of the Newborn Secondary to Rhesus Alloimmunization |
title_sort | early hyporegenerative anemia complicating hemolytic disease of the newborn secondary to rhesus alloimmunization |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673681/ https://www.ncbi.nlm.nih.gov/pubmed/34926072 http://dx.doi.org/10.7759/cureus.19603 |
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