Single-synapse analyses of Alzheimer’s disease implicate pathologic tau, DJ1, CD47, and ApoE

Synaptic molecular characterization is limited for Alzheimer’s disease (AD). Our newly invented mass cytometry–based method, synaptometry by time of flight (SynTOF), was used to measure 38 antibody probes in approximately 17 million single-synapse events from human brains without pathologic change o...

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Detalles Bibliográficos
Autores principales: Phongpreecha, Thanaphong, Gajera, Chandresh R., Liu, Candace C., Vijayaragavan, Kausalia, Chang, Alan L., Becker, Martin, Fallahzadeh, Ramin, Fernandez, Rosemary, Postupna, Nadia, Sherfield, Emily, Tebaykin, Dmitry, Latimer, Caitlin, Shively, Carol A., Register, Thomas C., Craft, Suzanne, Montine, Kathleen S., Fox, Edward J., Poston, Kathleen L., Keene, C. Dirk, Angelo, Michael, Bendall, Sean C., Aghaeepour, Nima, Montine, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673771/
https://www.ncbi.nlm.nih.gov/pubmed/34910503
http://dx.doi.org/10.1126/sciadv.abk0473

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