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Time-restricted feeding prevents deleterious metabolic effects of circadian disruption through epigenetic control of β cell function
Circadian rhythm disruption (CD) is associated with impaired glucose homeostasis and type 2 diabetes mellitus (T2DM). While the link between CD and T2DM remains unclear, there is accumulating evidence that disruption of fasting/feeding cycles mediates metabolic dysfunction. Here, we used an approach...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673777/ https://www.ncbi.nlm.nih.gov/pubmed/34910509 http://dx.doi.org/10.1126/sciadv.abg6856 |
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author | Brown, Matthew R. Sen, Satish K. Mazzone, Amelia Her, Tracy K. Xiong, Yuning Lee, Jeong-Heon Javeed, Naureen Colwell, Christopher S. Rakshit, Kuntol LeBrasseur, Nathan K. Gaspar-Maia, Alexandre Ordog, Tamas Matveyenko, Aleksey V. |
author_facet | Brown, Matthew R. Sen, Satish K. Mazzone, Amelia Her, Tracy K. Xiong, Yuning Lee, Jeong-Heon Javeed, Naureen Colwell, Christopher S. Rakshit, Kuntol LeBrasseur, Nathan K. Gaspar-Maia, Alexandre Ordog, Tamas Matveyenko, Aleksey V. |
author_sort | Brown, Matthew R. |
collection | PubMed |
description | Circadian rhythm disruption (CD) is associated with impaired glucose homeostasis and type 2 diabetes mellitus (T2DM). While the link between CD and T2DM remains unclear, there is accumulating evidence that disruption of fasting/feeding cycles mediates metabolic dysfunction. Here, we used an approach encompassing analysis of behavioral, physiological, transcriptomic, and epigenomic effects of CD and consequences of restoring fasting/feeding cycles through time-restricted feeding (tRF) in mice. Results show that CD perturbs glucose homeostasis through disruption of pancreatic β cell function and loss of circadian transcriptional and epigenetic identity. In contrast, restoration of fasting/feeding cycle prevented CD-mediated dysfunction by reestablishing circadian regulation of glucose tolerance, β cell function, transcriptional profile, and reestablishment of proline and acidic amino acid–rich basic leucine zipper (PAR bZIP) transcription factor DBP expression/activity. This study provides mechanistic insights into circadian regulation of β cell function and corresponding beneficial effects of tRF in prevention of β T2DM. |
format | Online Article Text |
id | pubmed-8673777 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-86737772021-12-28 Time-restricted feeding prevents deleterious metabolic effects of circadian disruption through epigenetic control of β cell function Brown, Matthew R. Sen, Satish K. Mazzone, Amelia Her, Tracy K. Xiong, Yuning Lee, Jeong-Heon Javeed, Naureen Colwell, Christopher S. Rakshit, Kuntol LeBrasseur, Nathan K. Gaspar-Maia, Alexandre Ordog, Tamas Matveyenko, Aleksey V. Sci Adv Biomedicine and Life Sciences Circadian rhythm disruption (CD) is associated with impaired glucose homeostasis and type 2 diabetes mellitus (T2DM). While the link between CD and T2DM remains unclear, there is accumulating evidence that disruption of fasting/feeding cycles mediates metabolic dysfunction. Here, we used an approach encompassing analysis of behavioral, physiological, transcriptomic, and epigenomic effects of CD and consequences of restoring fasting/feeding cycles through time-restricted feeding (tRF) in mice. Results show that CD perturbs glucose homeostasis through disruption of pancreatic β cell function and loss of circadian transcriptional and epigenetic identity. In contrast, restoration of fasting/feeding cycle prevented CD-mediated dysfunction by reestablishing circadian regulation of glucose tolerance, β cell function, transcriptional profile, and reestablishment of proline and acidic amino acid–rich basic leucine zipper (PAR bZIP) transcription factor DBP expression/activity. This study provides mechanistic insights into circadian regulation of β cell function and corresponding beneficial effects of tRF in prevention of β T2DM. American Association for the Advancement of Science 2021-12-15 /pmc/articles/PMC8673777/ /pubmed/34910509 http://dx.doi.org/10.1126/sciadv.abg6856 Text en Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Biomedicine and Life Sciences Brown, Matthew R. Sen, Satish K. Mazzone, Amelia Her, Tracy K. Xiong, Yuning Lee, Jeong-Heon Javeed, Naureen Colwell, Christopher S. Rakshit, Kuntol LeBrasseur, Nathan K. Gaspar-Maia, Alexandre Ordog, Tamas Matveyenko, Aleksey V. Time-restricted feeding prevents deleterious metabolic effects of circadian disruption through epigenetic control of β cell function |
title | Time-restricted feeding prevents deleterious metabolic effects of circadian disruption through epigenetic control of β cell function |
title_full | Time-restricted feeding prevents deleterious metabolic effects of circadian disruption through epigenetic control of β cell function |
title_fullStr | Time-restricted feeding prevents deleterious metabolic effects of circadian disruption through epigenetic control of β cell function |
title_full_unstemmed | Time-restricted feeding prevents deleterious metabolic effects of circadian disruption through epigenetic control of β cell function |
title_short | Time-restricted feeding prevents deleterious metabolic effects of circadian disruption through epigenetic control of β cell function |
title_sort | time-restricted feeding prevents deleterious metabolic effects of circadian disruption through epigenetic control of β cell function |
topic | Biomedicine and Life Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673777/ https://www.ncbi.nlm.nih.gov/pubmed/34910509 http://dx.doi.org/10.1126/sciadv.abg6856 |
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