ZHX2 promotes HIF1α oncogenic signaling in triple-negative breast cancer

Triple-negative breast cancer (TNBC) is an aggressive and highly lethal disease, which warrants the critical need to identify new therapeutic targets. We show that Zinc Fingers and Homeoboxes 2 (ZHX2) is amplified or overexpressed in TNBC cell lines and patients. Functionally, depletion of ZHX2 inhi...

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Detalles Bibliográficos
Autores principales: Fang, Wentong, Liao, Chengheng, Shi, Rachel, Simon, Jeremy M, Ptacek, Travis S, Zurlo, Giada, Ye, Youqiong, Han, Leng, Fan, Cheng, Bao, Lei, Ortiz, Christopher Llynard, Lin, Hong-Rui, Manocha, Ujjawal, Luo, Weibo, Peng, Yan, Kim, William Y, Yang, Lee-Wei, Zhang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673836/
https://www.ncbi.nlm.nih.gov/pubmed/34779768
http://dx.doi.org/10.7554/eLife.70412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673836/
https://www.ncbi.nlm.nih.gov/pubmed/34779768
http://dx.doi.org/10.7554/eLife.70412

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