Family History of Psychiatric Disorders and Clinical Factors Associated With a Schizophrenia Diagnosis

BACKGROUND: Schizophrenia (SCH) and bipolar disorder (BD) have both shared and unique genetic risk factors and clinical characteristics. The aim of the present study was to identify potential risk factors significantly associated with SCH, relative to a BD reference group. METHODS: Data were obtaine...

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Autores principales: Díaz-Castro, Lina, Hoffman, Kurt, Cabello-Rangel, Héctor, Arredondo, Armando, Herrera-Estrella, Miguel Ángel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673879/
https://www.ncbi.nlm.nih.gov/pubmed/34845937
http://dx.doi.org/10.1177/00469580211060797
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author Díaz-Castro, Lina
Hoffman, Kurt
Cabello-Rangel, Héctor
Arredondo, Armando
Herrera-Estrella, Miguel Ángel
author_facet Díaz-Castro, Lina
Hoffman, Kurt
Cabello-Rangel, Héctor
Arredondo, Armando
Herrera-Estrella, Miguel Ángel
author_sort Díaz-Castro, Lina
collection PubMed
description BACKGROUND: Schizophrenia (SCH) and bipolar disorder (BD) have both shared and unique genetic risk factors and clinical characteristics. The aim of the present study was to identify potential risk factors significantly associated with SCH, relative to a BD reference group. METHODS: Data were obtained from medical records of patients that entered a major Mexico City hospital during 2009–2010 presenting psychotic symptoms (n = 1132; 830 cases of SCH, 302 cases of BD; 714 men and 418 women). SCH and BD diagnoses were compared with respect to a number of family and clinical characteristics. Logistic and linear regression analyses were used to respectively identify factors selectively associated with the SCH diagnosis relative to the BD diagnosis and explore the relationship between PANSS scores and parental age at time of birth to the age of SCH onset. RESULTS: Patients with SCH showed greater functional impairment than those with BD. Family history of mental illness, premorbid schizoid-like personality, and obstetric trauma were significantly associated with the SCH diagnosis. The association of obstetric trauma with SCH was greatest in male patients with a family history of mental illness. In women, increased paternal and decreased maternal age at time of the patient’s birth were associated with an earlier age of SCH onset. CONCLUSION: Male gender, showing premorbid schizoid-like personality, familial SCH, and obstetric trauma are risk factors that distinguish SCH from BD. Additionally, our results suggest that risk for SCH relative to BD may be importantly influenced by interactions between familial risk, gender, and obstetric trauma.
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spelling pubmed-86738792021-12-16 Family History of Psychiatric Disorders and Clinical Factors Associated With a Schizophrenia Diagnosis Díaz-Castro, Lina Hoffman, Kurt Cabello-Rangel, Héctor Arredondo, Armando Herrera-Estrella, Miguel Ángel Inquiry Original Research Article BACKGROUND: Schizophrenia (SCH) and bipolar disorder (BD) have both shared and unique genetic risk factors and clinical characteristics. The aim of the present study was to identify potential risk factors significantly associated with SCH, relative to a BD reference group. METHODS: Data were obtained from medical records of patients that entered a major Mexico City hospital during 2009–2010 presenting psychotic symptoms (n = 1132; 830 cases of SCH, 302 cases of BD; 714 men and 418 women). SCH and BD diagnoses were compared with respect to a number of family and clinical characteristics. Logistic and linear regression analyses were used to respectively identify factors selectively associated with the SCH diagnosis relative to the BD diagnosis and explore the relationship between PANSS scores and parental age at time of birth to the age of SCH onset. RESULTS: Patients with SCH showed greater functional impairment than those with BD. Family history of mental illness, premorbid schizoid-like personality, and obstetric trauma were significantly associated with the SCH diagnosis. The association of obstetric trauma with SCH was greatest in male patients with a family history of mental illness. In women, increased paternal and decreased maternal age at time of the patient’s birth were associated with an earlier age of SCH onset. CONCLUSION: Male gender, showing premorbid schizoid-like personality, familial SCH, and obstetric trauma are risk factors that distinguish SCH from BD. Additionally, our results suggest that risk for SCH relative to BD may be importantly influenced by interactions between familial risk, gender, and obstetric trauma. SAGE Publications 2021-11-30 /pmc/articles/PMC8673879/ /pubmed/34845937 http://dx.doi.org/10.1177/00469580211060797 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research Article
Díaz-Castro, Lina
Hoffman, Kurt
Cabello-Rangel, Héctor
Arredondo, Armando
Herrera-Estrella, Miguel Ángel
Family History of Psychiatric Disorders and Clinical Factors Associated With a Schizophrenia Diagnosis
title Family History of Psychiatric Disorders and Clinical Factors Associated With a Schizophrenia Diagnosis
title_full Family History of Psychiatric Disorders and Clinical Factors Associated With a Schizophrenia Diagnosis
title_fullStr Family History of Psychiatric Disorders and Clinical Factors Associated With a Schizophrenia Diagnosis
title_full_unstemmed Family History of Psychiatric Disorders and Clinical Factors Associated With a Schizophrenia Diagnosis
title_short Family History of Psychiatric Disorders and Clinical Factors Associated With a Schizophrenia Diagnosis
title_sort family history of psychiatric disorders and clinical factors associated with a schizophrenia diagnosis
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673879/
https://www.ncbi.nlm.nih.gov/pubmed/34845937
http://dx.doi.org/10.1177/00469580211060797
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