Zoonotic spill-over of SARS-CoV-2: mink-adapted virus in humans

OBJECTIVES: This work aimed to analyse possible zoonotic spill-over of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report the spill-over of mink-adapted SARS-CoV-2 from farmed mink to humans after adaptation that lasted at least 3 months. METHODS: Next-generation sequencing and...

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Detalles Bibliográficos
Autores principales: Rabalski, Lukasz, Kosinski, Maciej, Mazur-Panasiuk, Natalia, Szewczyk, Boguslaw, Bienkowska-Szewczyk, Krystyna, Kant, Ravi, Sironen, Tarja, Pyrc, Krzysztof, Grzybek, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. 2022
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673923/
https://www.ncbi.nlm.nih.gov/pubmed/34920116
http://dx.doi.org/10.1016/j.cmi.2021.12.001
Descripción
Sumario:OBJECTIVES: This work aimed to analyse possible zoonotic spill-over of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report the spill-over of mink-adapted SARS-CoV-2 from farmed mink to humans after adaptation that lasted at least 3 months. METHODS: Next-generation sequencing and a bioinformatic approach were applied to analyse the data. RESULTS: In an isolate obtained from an asymptomatic patient testing positive for SARS-CoV-2, we found four distinguishing mutations in the S gene that gave rise to the mink-adapted variant (G75V, M177T, Y453F, and C1247F) and others. CONCLUSIONS: Zoonotic spill-over of SARS-CoV-2 can occur from mink to human.

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