Zoonotic spill-over of SARS-CoV-2: mink-adapted virus in humans

OBJECTIVES: This work aimed to analyse possible zoonotic spill-over of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report the spill-over of mink-adapted SARS-CoV-2 from farmed mink to humans after adaptation that lasted at least 3 months. METHODS: Next-generation sequencing and...

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Autores principales: Rabalski, Lukasz, Kosinski, Maciej, Mazur-Panasiuk, Natalia, Szewczyk, Boguslaw, Bienkowska-Szewczyk, Krystyna, Kant, Ravi, Sironen, Tarja, Pyrc, Krzysztof, Grzybek, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. 2022
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673923/
https://www.ncbi.nlm.nih.gov/pubmed/34920116
http://dx.doi.org/10.1016/j.cmi.2021.12.001
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author Rabalski, Lukasz
Kosinski, Maciej
Mazur-Panasiuk, Natalia
Szewczyk, Boguslaw
Bienkowska-Szewczyk, Krystyna
Kant, Ravi
Sironen, Tarja
Pyrc, Krzysztof
Grzybek, Maciej
author_facet Rabalski, Lukasz
Kosinski, Maciej
Mazur-Panasiuk, Natalia
Szewczyk, Boguslaw
Bienkowska-Szewczyk, Krystyna
Kant, Ravi
Sironen, Tarja
Pyrc, Krzysztof
Grzybek, Maciej
author_sort Rabalski, Lukasz
collection PubMed
description OBJECTIVES: This work aimed to analyse possible zoonotic spill-over of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report the spill-over of mink-adapted SARS-CoV-2 from farmed mink to humans after adaptation that lasted at least 3 months. METHODS: Next-generation sequencing and a bioinformatic approach were applied to analyse the data. RESULTS: In an isolate obtained from an asymptomatic patient testing positive for SARS-CoV-2, we found four distinguishing mutations in the S gene that gave rise to the mink-adapted variant (G75V, M177T, Y453F, and C1247F) and others. CONCLUSIONS: Zoonotic spill-over of SARS-CoV-2 can occur from mink to human.
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spelling pubmed-86739232021-12-16 Zoonotic spill-over of SARS-CoV-2: mink-adapted virus in humans Rabalski, Lukasz Kosinski, Maciej Mazur-Panasiuk, Natalia Szewczyk, Boguslaw Bienkowska-Szewczyk, Krystyna Kant, Ravi Sironen, Tarja Pyrc, Krzysztof Grzybek, Maciej Clin Microbiol Infect Research Note OBJECTIVES: This work aimed to analyse possible zoonotic spill-over of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report the spill-over of mink-adapted SARS-CoV-2 from farmed mink to humans after adaptation that lasted at least 3 months. METHODS: Next-generation sequencing and a bioinformatic approach were applied to analyse the data. RESULTS: In an isolate obtained from an asymptomatic patient testing positive for SARS-CoV-2, we found four distinguishing mutations in the S gene that gave rise to the mink-adapted variant (G75V, M177T, Y453F, and C1247F) and others. CONCLUSIONS: Zoonotic spill-over of SARS-CoV-2 can occur from mink to human. European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. 2022-03 2021-12-15 /pmc/articles/PMC8673923/ /pubmed/34920116 http://dx.doi.org/10.1016/j.cmi.2021.12.001 Text en © 2021 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Research Note
Rabalski, Lukasz
Kosinski, Maciej
Mazur-Panasiuk, Natalia
Szewczyk, Boguslaw
Bienkowska-Szewczyk, Krystyna
Kant, Ravi
Sironen, Tarja
Pyrc, Krzysztof
Grzybek, Maciej
Zoonotic spill-over of SARS-CoV-2: mink-adapted virus in humans
title Zoonotic spill-over of SARS-CoV-2: mink-adapted virus in humans
title_full Zoonotic spill-over of SARS-CoV-2: mink-adapted virus in humans
title_fullStr Zoonotic spill-over of SARS-CoV-2: mink-adapted virus in humans
title_full_unstemmed Zoonotic spill-over of SARS-CoV-2: mink-adapted virus in humans
title_short Zoonotic spill-over of SARS-CoV-2: mink-adapted virus in humans
title_sort zoonotic spill-over of sars-cov-2: mink-adapted virus in humans
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673923/
https://www.ncbi.nlm.nih.gov/pubmed/34920116
http://dx.doi.org/10.1016/j.cmi.2021.12.001
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