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Vaccine effectiveness against COVID-19 hospitalization in adults in France: A test negative case control study

BACKGROUND: Measuring vaccine effectiveness (VE) using real-life data is critical to confirm the effectiveness of licensed vaccine, which could strengthen vaccination adherence. METHODS: We measured VE against adult COVID-19 hospitalization in five hospitals in France using a test negative design. W...

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Autores principales: Luong Nguyen, Liem Binh, Bauer, Rebecca, Lesieur, Zineb, Galtier, Florence, Duval, Xavier, Vanhems, Philippe, Lainé, Fabrice, Tattevin, Pierre, Durier, Christine, Launay, Odile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673927/
https://www.ncbi.nlm.nih.gov/pubmed/34920180
http://dx.doi.org/10.1016/j.idnow.2021.12.002
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author Luong Nguyen, Liem Binh
Bauer, Rebecca
Lesieur, Zineb
Galtier, Florence
Duval, Xavier
Vanhems, Philippe
Lainé, Fabrice
Tattevin, Pierre
Durier, Christine
Launay, Odile
author_facet Luong Nguyen, Liem Binh
Bauer, Rebecca
Lesieur, Zineb
Galtier, Florence
Duval, Xavier
Vanhems, Philippe
Lainé, Fabrice
Tattevin, Pierre
Durier, Christine
Launay, Odile
author_sort Luong Nguyen, Liem Binh
collection PubMed
description BACKGROUND: Measuring vaccine effectiveness (VE) using real-life data is critical to confirm the effectiveness of licensed vaccine, which could strengthen vaccination adherence. METHODS: We measured VE against adult COVID-19 hospitalization in five hospitals in France using a test negative design. We compared the odds of vaccinated patients hospitalized with COVID-19 with the odds of vaccinated patients hospitalized for the same symptoms with a negative test. RESULTS: A total of 853 patients (463 cases and 390 controls) were included, with a total of 170 patients vaccinated (104 with one dose, 65 with two doses, and one with three doses). There were four cases of breakthrough infections, all in immunocompromised patients. The VE was 84.0% (CI(0.95) = [72.6; 90.6]) for one dose and 96.2% (CI(0.95) = [86.8; 98.9]) for two doses. CONCLUSION: Our results confirm the high VE of COVID-19 vaccine in France to prevent hospitalizations due to the alpha variant.
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spelling pubmed-86739272021-12-16 Vaccine effectiveness against COVID-19 hospitalization in adults in France: A test negative case control study Luong Nguyen, Liem Binh Bauer, Rebecca Lesieur, Zineb Galtier, Florence Duval, Xavier Vanhems, Philippe Lainé, Fabrice Tattevin, Pierre Durier, Christine Launay, Odile Infect Dis Now Short Communication BACKGROUND: Measuring vaccine effectiveness (VE) using real-life data is critical to confirm the effectiveness of licensed vaccine, which could strengthen vaccination adherence. METHODS: We measured VE against adult COVID-19 hospitalization in five hospitals in France using a test negative design. We compared the odds of vaccinated patients hospitalized with COVID-19 with the odds of vaccinated patients hospitalized for the same symptoms with a negative test. RESULTS: A total of 853 patients (463 cases and 390 controls) were included, with a total of 170 patients vaccinated (104 with one dose, 65 with two doses, and one with three doses). There were four cases of breakthrough infections, all in immunocompromised patients. The VE was 84.0% (CI(0.95) = [72.6; 90.6]) for one dose and 96.2% (CI(0.95) = [86.8; 98.9]) for two doses. CONCLUSION: Our results confirm the high VE of COVID-19 vaccine in France to prevent hospitalizations due to the alpha variant. Elsevier Masson SAS. 2022-02 2021-12-15 /pmc/articles/PMC8673927/ /pubmed/34920180 http://dx.doi.org/10.1016/j.idnow.2021.12.002 Text en © 2021 Elsevier Masson SAS. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Luong Nguyen, Liem Binh
Bauer, Rebecca
Lesieur, Zineb
Galtier, Florence
Duval, Xavier
Vanhems, Philippe
Lainé, Fabrice
Tattevin, Pierre
Durier, Christine
Launay, Odile
Vaccine effectiveness against COVID-19 hospitalization in adults in France: A test negative case control study
title Vaccine effectiveness against COVID-19 hospitalization in adults in France: A test negative case control study
title_full Vaccine effectiveness against COVID-19 hospitalization in adults in France: A test negative case control study
title_fullStr Vaccine effectiveness against COVID-19 hospitalization in adults in France: A test negative case control study
title_full_unstemmed Vaccine effectiveness against COVID-19 hospitalization in adults in France: A test negative case control study
title_short Vaccine effectiveness against COVID-19 hospitalization in adults in France: A test negative case control study
title_sort vaccine effectiveness against covid-19 hospitalization in adults in france: a test negative case control study
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673927/
https://www.ncbi.nlm.nih.gov/pubmed/34920180
http://dx.doi.org/10.1016/j.idnow.2021.12.002
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