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Modeling the number of people infected with SARS-COV-2 from wastewater viral load in Northwest Spain

The quantification of the SARS-CoV-2 RNA load in wastewater has emerged as a useful tool to monitor COVID–19 outbreaks in the community. This approach was implemented in the metropolitan area of A Coruña (NW Spain), where wastewater from a treatment plant was analyzed to track the epidemic dynamics...

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Detalles Bibliográficos
Autores principales: Vallejo, Juan A., Trigo-Tasende, Noelia, Rumbo-Feal, Soraya, Conde-Pérez, Kelly, López-Oriona, Ángel, Barbeito, Inés, Vaamonde, Manuel, Tarrío-Saavedra, Javier, Reif, Rubén, Ladra, Susana, Rodiño-Janeiro, Bruno K., Nasser-Ali, Mohammed, Cid, Ángeles, Veiga, María, Acevedo, Antón, Lamora, Carlos, Bou, Germán, Cao, Ricardo, Poza, Margarita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674110/
https://www.ncbi.nlm.nih.gov/pubmed/34921882
http://dx.doi.org/10.1016/j.scitotenv.2021.152334
Descripción
Sumario:The quantification of the SARS-CoV-2 RNA load in wastewater has emerged as a useful tool to monitor COVID–19 outbreaks in the community. This approach was implemented in the metropolitan area of A Coruña (NW Spain), where wastewater from a treatment plant was analyzed to track the epidemic dynamics in a population of 369,098 inhabitants. Viral load detected in the wastewater and the epidemiological data from A Coruña health system served as main sources for statistical models developing. Regression models described here allowed us to estimate the number of infected people (R(2) = 0.9), including symptomatic and asymptomatic individuals. These models have helped to understand the real magnitude of the epidemic in a population at any given time and have been used as an effective early warning tool for predicting outbreaks in A Coruña municipality. The methodology of the present work could be used to develop a similar wastewater-based epidemiological model to track the evolution of the COVID–19 epidemic anywhere in the world where centralized water-based sanitation systems exist.