Cargando…

Accuracy mechanism of eukaryotic ribosome translocation

Translation of the genetic code into proteins is realized through repetitions of synchronous translocation of messenger RNA (mRNA) and transfer RNAs (tRNA) through the ribosome. In eukaryotes translocation is ensured by elongation factor 2 (eEF2), which catalyses the process and actively contributes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Djumagulov, Muminjon, Demeshkina, Natalia, Jenner, Lasse, Rozov, Alexey, Yusupov, Marat, Yusupova, Gulnara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674143/ https://www.ncbi.nlm.nih.gov/pubmed/34853469 http://dx.doi.org/10.1038/s41586-021-04131-9

Ejemplares similares

Aminoglycoside interactions and impacts on the eukaryotic ribosome
por: Prokhorova, Irina, et al.
Publicado: (2017)

Structural insights into the translational infidelity mechanism
por: Rozov, Alexey, et al.
Publicado: (2015)

Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code
por: Rozov, Alexey, et al.
Publicado: (2016)

The ribosome prohibits the G•U wobble geometry at the first position of the codon–anticodon helix
por: Rozov, Alexey, et al.
Publicado: (2016)

Inhibition of the Eukaryotic 80S Ribosome as a Potential Anticancer Therapy: A Structural Perspective
por: Pellegrino, Simone, et al.
Publicado: (2021)

Tautomeric G•U pairs within the molecular ribosomal grip and fidelity of decoding in bacteria
por: Rozov, Alexey, et al.
Publicado: (2018)

Ribosome biochemistry in crystal structure determination
por: Yusupova, Gulnara, et al.
Publicado: (2015)

Importance of potassium ions for ribosome structure and function revealed by long-wavelength X-ray diffraction
por: Rozov, Alexey, et al.
Publicado: (2019)

Insights into the origin of the nuclear localization signals in conserved ribosomal proteins
por: Melnikov, Sergey, et al.
Publicado: (2015)

Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome
por: Prokhorova, Irina V., et al.
Publicado: (2016)

Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome
por: Pellegrino, Simone, et al.
Publicado: (2019)

E-site drug specificity of the human pathogen Candida albicans ribosome
por: Zgadzay, Yury, et al.
Publicado: (2022)

Crystal Structures of the uL3 Mutant Ribosome: Illustration of the Importance of Ribosomal Proteins for Translation Efficiency
por: Mailliot, Justine, et al.
Publicado: (2016)

Cryo-EM structure of the hibernating Thermus thermophilus 100S ribosome reveals a protein-mediated dimerization mechanism
por: Flygaard, Rasmus Kock, et al.
Publicado: (2018)

Recognition of Watson-Crick base pairs: constraints and limits due to geometric selection and tautomerism
por: Westhof, Eric, et al.
Publicado: (2014)

The multiple flavors of GoU pairs in RNA
por: Westhof, Eric, et al.
Publicado: (2019)

Novel activity of eukaryotic translocase, eEF2: dissociation of the 80S ribosome into subunits with ATP but not with GTP
por: Demeshkina, Natalia, et al.
Publicado: (2007)

Novel activity of eukaryotic translocase, eEF2: dissociation of the 80S ribosome into subunits with ATP but not with GTP
por: Demeshkina, Natalia, et al.
Publicado: (2007)

Structure of the 70S ribosome from human pathogen Staphylococcus aureus
por: Khusainov, Iskander, et al.
Publicado: (2016)

Structure of the 70S ribosome from human pathogen Staphylococcus aureus
por: Khusainov, Iskander, et al.
Publicado: (2017)

Mechanism of ribosome shutdown by RsfS in Staphylococcus aureus revealed by integrative structural biology approach
por: Khusainov, Iskander, et al.
Publicado: (2020)

Posttranslational modification of Elongation Factor P from Staphylococcus aureus
por: Golubev, Alexander, et al.
Publicado: (2020)

tRNA Translocation by the Eukaryotic 80S Ribosome and the Impact of GTP Hydrolysis
por: Flis, Julia, et al.
Publicado: (2018)

Co-Assembly of 40S and 60S Ribosomal Proteins in Early Steps of Eukaryotic Ribosome Assembly
por: Fox, Jesse M., et al.
Publicado: (2019)

High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation
por: Kišonaitė, Miglė, et al.
Publicado: (2022)

Assembly of ribosomes in eukaryotes
por: Woolford, John
Publicado: (2015)

Insights into the mechanisms of eukaryotic translation gained with ribosome profiling
por: Andreev, Dmitry E., et al.
Publicado: (2017)

Inhibiting eukaryotic ribosome biogenesis
por: Awad, Dominik, et al.
Publicado: (2019)

Movement in ribosome translocation
por: Fraser, Christopher S, et al.
Publicado: (2005)

Stabilization of Ribosomal RNA of the Small Subunit by Spermidine in Staphylococcus aureus
por: Belinite, Margarita, et al.
Publicado: (2021)

Direct measurement of the mechanical work during translocation by the ribosome
por: Liu, Tingting, et al.
Publicado: (2014)

Coordinated conformational and compositional dynamics drive ribosome translocation
por: Chen, Jin, et al.
Publicado: (2013)

Eukaryotic Ribosome Biogenesis: The 40S Subunit
por: Moraleva, A. A., et al.
Publicado: (2022)

Eukaryotic Ribosome Biogenesis: The 60S Subunit
por: Moraleva, A. A., et al.
Publicado: (2022)

Shaping the Nascent Ribosome: AAA-ATPases in Eukaryotic Ribosome Biogenesis
por: Prattes, Michael, et al.
Publicado: (2019)

Cryo-electron microscopy structure and translocation mechanism of the crenarchaeal ribosome
por: Wang, Ying-Hui, et al.
Publicado: (2023)

The GTPase switch in ribosomal translocation
por: Moore, Pete
Publicado: (2005)

Structural insights into ribosome translocation
por: Ling, Clarence, et al.
Publicado: (2016)

The Eukaryotic Ribosome: Current Status and Challenges
por: Dinman, Jonathan D.
Publicado: (2009)

Interaction of tRNA with Eukaryotic Ribosome
por: Graifer, Dmitri, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_hp1gdh4a6vlpkg8pjamdug49q2