Membrane-bound IL-6R is upregulated on Th17 cells and inhibits Treg cell migration by regulating post-translational modification of VASP in autoimmune arthritis

Autoimmune arthritis is characterized by impaired regulatory T (Treg) cell migration into inflamed joint tissue and by dysregulation of the balance between Treg cells and Th17 cells. Interleukin-6 (IL-6) is known to contribute to this dysregulation, but the molecular mechanisms behind impaired Treg...

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Detalles Bibliográficos
Autores principales: Yan, Shuaifeng, Golumba-Nagy, Viktoria, Kotschenreuther, Konstantin, Thiele, Jan, Refaian, Nasrin, Shuya, Deng, Gloyer, Lydia, Dittrich-Salamon, Mara, Meyer, Anja, Heindl, Ludwig M., Kofler, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674172/
https://www.ncbi.nlm.nih.gov/pubmed/34913099
http://dx.doi.org/10.1007/s00018-021-04076-2

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