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The Impact of Tumor Mutation Burden on the Effect of Frontline Trastuzumab Plus Chemotherapy in Human Epidermal Growth Factor Receptor 2-Positive Advanced Gastric Cancers

BACKGROUND: Trastuzumab is a HER2-trargeted humanized monoclonal antibody that has been studied as a first-line treatment for patients with HER2-positive advanced gastric cancer (AGC). The effect of anti-HER2 therapy according to tumor mutational burden (TMB) in HER2-positive AGC remains unclear. ME...

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Detalles Bibliográficos
Autores principales:	Kim, Hye Ryeon, Ahn, Soomin, Jo, Hyunji, Kim, Hongsik, Hong, Joohyun, Lee, Jeeyun, Lim, Ho-Yeong, Kang, Won Ki, Kim, Seung Tae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674178/ https://www.ncbi.nlm.nih.gov/pubmed/34926309 http://dx.doi.org/10.3389/fonc.2021.792340

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