MicroSEC filters sequence errors for formalin-fixed and paraffin-embedded samples

The clinical sequencing of tumors is usually performed on formalin-fixed, paraffin-embedded samples and results in many sequencing errors. We identified that most of these errors are detected in chimeric reads caused by single-strand DNA molecules with microhomology. During the end-repair step of li...

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Detalles Bibliográficos
Autores principales: Ikegami, Masachika, Kohsaka, Shinji, Hirose, Takeshi, Ueno, Toshihide, Inoue, Satoshi, Kanomata, Naoki, Yamauchi, Hideko, Mori, Taisuke, Sekine, Shigeki, Inamoto, Yoshihiro, Yatabe, Yasushi, Kobayashi, Hiroshi, Tanaka, Sakae, Mano, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674242/
https://www.ncbi.nlm.nih.gov/pubmed/34912045
http://dx.doi.org/10.1038/s42003-021-02930-4

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