Cargando…
Gut bacterial tyrosine decarboxylase associates with clinical variables in a longitudinal cohort study of Parkinsons disease
Gut microbiota influences the clinical response of a wide variety of orally administered drugs. However, the underlying mechanisms through which drug–microbiota interactions occur are still obscure. Previously, we reported that tyrosine decarboxylating (TDC) bacteria may restrict the levels of levod...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674283/ https://www.ncbi.nlm.nih.gov/pubmed/34911958 http://dx.doi.org/10.1038/s41531-021-00260-0 |
_version_ | 1784615614923407360 |
---|---|
author | van Kessel, Sebastiaan P. Auvinen, Petri Scheperjans, Filip El Aidy, Sahar |
author_facet | van Kessel, Sebastiaan P. Auvinen, Petri Scheperjans, Filip El Aidy, Sahar |
author_sort | van Kessel, Sebastiaan P. |
collection | PubMed |
description | Gut microbiota influences the clinical response of a wide variety of orally administered drugs. However, the underlying mechanisms through which drug–microbiota interactions occur are still obscure. Previously, we reported that tyrosine decarboxylating (TDC) bacteria may restrict the levels of levodopa reaching circulation in patients with Parkinson’s disease (PD). We observed a significant positive association between disease duration and the abundance of the bacterial tdc-gene. The question arises whether increased exposure to anti-PD medication could affect the abundance of bacterial TDC, to ultimately impact drug efficacy. To this end, we investigated the potential association between anti-PD drug exposure and bacterial tdc-gene abundance over a period of 2 years in a longitudinal cohort of PD patients and healthy controls. Our data reveal significant associations between tdc-gene abundance, several anti-PD medications, including entacapone, rasagiline, pramipexole, and ropinirole but not levodopa, and gastrointestinal symptoms, warranting further research on the effect of anti-PD medication on microbial changes and gastrointestinal function. |
format | Online Article Text |
id | pubmed-8674283 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-86742832022-01-04 Gut bacterial tyrosine decarboxylase associates with clinical variables in a longitudinal cohort study of Parkinsons disease van Kessel, Sebastiaan P. Auvinen, Petri Scheperjans, Filip El Aidy, Sahar NPJ Parkinsons Dis Article Gut microbiota influences the clinical response of a wide variety of orally administered drugs. However, the underlying mechanisms through which drug–microbiota interactions occur are still obscure. Previously, we reported that tyrosine decarboxylating (TDC) bacteria may restrict the levels of levodopa reaching circulation in patients with Parkinson’s disease (PD). We observed a significant positive association between disease duration and the abundance of the bacterial tdc-gene. The question arises whether increased exposure to anti-PD medication could affect the abundance of bacterial TDC, to ultimately impact drug efficacy. To this end, we investigated the potential association between anti-PD drug exposure and bacterial tdc-gene abundance over a period of 2 years in a longitudinal cohort of PD patients and healthy controls. Our data reveal significant associations between tdc-gene abundance, several anti-PD medications, including entacapone, rasagiline, pramipexole, and ropinirole but not levodopa, and gastrointestinal symptoms, warranting further research on the effect of anti-PD medication on microbial changes and gastrointestinal function. Nature Publishing Group UK 2021-12-15 /pmc/articles/PMC8674283/ /pubmed/34911958 http://dx.doi.org/10.1038/s41531-021-00260-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article van Kessel, Sebastiaan P. Auvinen, Petri Scheperjans, Filip El Aidy, Sahar Gut bacterial tyrosine decarboxylase associates with clinical variables in a longitudinal cohort study of Parkinsons disease |
title | Gut bacterial tyrosine decarboxylase associates with clinical variables in a longitudinal cohort study of Parkinsons disease |
title_full | Gut bacterial tyrosine decarboxylase associates with clinical variables in a longitudinal cohort study of Parkinsons disease |
title_fullStr | Gut bacterial tyrosine decarboxylase associates with clinical variables in a longitudinal cohort study of Parkinsons disease |
title_full_unstemmed | Gut bacterial tyrosine decarboxylase associates with clinical variables in a longitudinal cohort study of Parkinsons disease |
title_short | Gut bacterial tyrosine decarboxylase associates with clinical variables in a longitudinal cohort study of Parkinsons disease |
title_sort | gut bacterial tyrosine decarboxylase associates with clinical variables in a longitudinal cohort study of parkinsons disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674283/ https://www.ncbi.nlm.nih.gov/pubmed/34911958 http://dx.doi.org/10.1038/s41531-021-00260-0 |
work_keys_str_mv | AT vankesselsebastiaanp gutbacterialtyrosinedecarboxylaseassociateswithclinicalvariablesinalongitudinalcohortstudyofparkinsonsdisease AT auvinenpetri gutbacterialtyrosinedecarboxylaseassociateswithclinicalvariablesinalongitudinalcohortstudyofparkinsonsdisease AT scheperjansfilip gutbacterialtyrosinedecarboxylaseassociateswithclinicalvariablesinalongitudinalcohortstudyofparkinsonsdisease AT elaidysahar gutbacterialtyrosinedecarboxylaseassociateswithclinicalvariablesinalongitudinalcohortstudyofparkinsonsdisease |