Cargando…

Association between polygenic risk for Alzheimer’s disease, brain structure and cognitive abilities in UK Biobank

Previous studies testing associations between polygenic risk for late-onset Alzheimer’s disease (LOAD-PGR) and brain magnetic resonance imaging (MRI) measures have been limited by small samples and inconsistent consideration of potential confounders. This study investigates whether higher LOAD-PGR i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tank, Rachana, Ward, Joey, Flegal, Kristin E., Smith, Daniel J., Bailey, Mark E. S., Cavanagh, Jonathan, Lyall, Donald M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674313/ https://www.ncbi.nlm.nih.gov/pubmed/34621014 http://dx.doi.org/10.1038/s41386-021-01190-4

Ejemplares similares

The associations between self-reported depression, self-reported chronic inflammatory conditions and cognitive abilities in UK Biobank
por: Lyall, Laura M., et al.
Publicado: (2019)

Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association with Mood Instability
por: Ferguson, Amy, et al.
Publicado: (2018)

Carotid Intima-Media Thickness: Novel Loci, Sex-Specific Effects, and Genetic Correlations With Obesity and Glucometabolic Traits in UK Biobank
por: Strawbridge, Rona J., et al.
Publicado: (2020)

Identification of novel genome-wide associations for suicidality in UK Biobank, genetic correlation with psychiatric disorders and polygenic association with completed suicide
por: Strawbridge, Rona J., et al.
Publicado: (2019)

The association between C-reactive protein, mood disorder, and cognitive function in UK Biobank
por: Milton, David C., et al.
Publicado: (2021)

Quantifying bias in psychological and physical health in the UK Biobank imaging sub-sample
por: Lyall, Donald M., et al.
Publicado: (2022)

Phenotypic and genetic associations between anhedonia and brain structure in UK Biobank
por: Zhu, Xingxing, et al.
Publicado: (2021)

Cross-sectional and longitudinal analyses of outdoor air pollution exposure and cognitive function in UK Biobank
por: Cullen, Breda, et al.
Publicado: (2018)

Exploring the Role of Contactins across Psychological, Psychiatric and Cardiometabolic Traits within UK Biobank
por: Morris, Julia, et al.
Publicado: (2020)

Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank
por: Gouveia, Catarina, et al.
Publicado: (2022)

Reduced signal for polygenic adaptation of height in UK Biobank
por: Berg, Jeremy J, et al.
Publicado: (2019)

Associations between single and multiple cardiometabolic diseases and cognitive abilities in 474 129 UK Biobank participants
por: Lyall, Donald M., et al.
Publicado: (2017)

Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia
por: Ward, Joey, et al.
Publicado: (2017)

Impact of major depression on cardiovascular outcomes for individuals with hypertension: prospective survival analysis in UK Biobank
por: Graham, Nicholas, et al.
Publicado: (2019)

Diet and general cognitive ability in the UK Biobank dataset
por: Hepsomali, Piril, et al.
Publicado: (2021)

Polygenic risk for schizophrenia and subcortical brain anatomy in the UK Biobank cohort
por: Grama, Steluta, et al.
Publicado: (2020)

Genetic analysis of the PCSK9 locus in psychological, psychiatric, metabolic and cardiovascular traits in UK Biobank
por: Hay, Rachel, et al.
Publicado: (2022)

Genome-wide analysis of self-reported risk-taking behaviour and cross-disorder genetic correlations in the UK Biobank cohort
por: Strawbridge, Rona J., et al.
Publicado: (2018)

Associations of rheumatoid arthritis and rheumatoid factor with mental health, sleep and cognition characteristics in the UK Biobank
por: Stanciu, Ioana, et al.
Publicado: (2022)

Haplotype-based association analysis of general cognitive ability in Generation Scotland, the English Longitudinal Study of Ageing, and UK Biobank
por: Howard, David M., et al.
Publicado: (2017)

Canalization of the Polygenic Risk for Common Diseases and Traits in the UK Biobank Cohort
por: Nagpal, Sini, et al.
Publicado: (2022)

Assessing agreement between different polygenic risk scores in the UK Biobank
por: Clifton, Lei, et al.
Publicado: (2022)

Polygenic signals of sex differences in selection in humans from the UK Biobank
por: Ruzicka, Filip, et al.
Publicado: (2022)

Exploring polygenic‐environment and residual‐environment interactions for depressive symptoms within the UK Biobank
por: Gillett, Alexandra C., et al.
Publicado: (2022)

Significant sparse polygenic risk scores across 813 traits in UK Biobank
por: Tanigawa, Yosuke, et al.
Publicado: (2022)

Testing for association between exonic glucagon‐like peptide 1 receptor mutation with physical and brain health traits in UK Biobank
por: Ward, Joey, et al.
Publicado: (2022)

Genome-wide association study of multisite chronic pain in UK Biobank
por: Johnston, Keira J. A., et al.
Publicado: (2019)

Living alone, loneliness and lack of emotional support as predictors of suicide and self-harm: A nine-year follow up of the UK Biobank cohort
por: Shaw, Richard J., et al.
Publicado: (2021)

Novel genome-wide associations for anhedonia, genetic correlation with psychiatric disorders, and polygenic association with brain structure
por: Ward, Joey, et al.
Publicado: (2019)

Psychosocial predictors of COVID-19 infection in UK biobank (N = 104 201)
por: Wauye, Victor M, et al.
Publicado: (2023)

The effects of polygenic risk for psychiatric disorders and smoking behaviour on psychotic experiences in UK Biobank
por: García-González, Judit, et al.
Publicado: (2020)

Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank
por: Winterton, Adriano, et al.
Publicado: (2021)

Calculating Polygenic Risk Scores (PRS) in UK Biobank: A Practical Guide for Epidemiologists
por: Collister, Jennifer A., et al.
Publicado: (2022)

The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function
por: Ward, Joey, et al.
Publicado: (2020)

Polygenic risk of ischemic stroke is associated with cognitive ability
por: Harris, Sarah E., et al.
Publicado: (2016)

Polygenic predictors of age-related decline in cognitive ability
por: Ritchie, Stuart J., et al.
Publicado: (2019)

Cognitive Test Scores in UK Biobank: Data Reduction in 480,416 Participants and Longitudinal Stability in 20,346 Participants
por: Lyall, Donald M., et al.
Publicado: (2016)

Correction: The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function
por: Ward, Joey, et al.
Publicado: (2019)

Association of polygenic risk for major psychiatric illness with subcortical volumes and white matter integrity in UK Biobank
por: Reus, L. M., et al.
Publicado: (2017)

Correction: Cognitive Test Scores in UK Biobank: Data Reduction in 480,416 Participants and Longitudinal Stability in 20,346 Participants
por: Lyall, Donald M., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_i8ignscec3t98psg9lr7tdglhn