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Peptidyl transferase center decompaction and structural constraints during early protein elongation on the ribosome

Peptide bond formation on the ribosome requires that aminoacyl-tRNAs and peptidyl-tRNAs are properly positioned on the A site and the P site of the peptidyl transferase center (PTC) so that nucleophilic attack can occur. Here we analyse some constraints associated with the induced-fit mechanism of t...

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Detalles Bibliográficos
Autores principales:	Jia, Bin, Wang, Tianlong, Lehmann, Jean
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674327/ https://www.ncbi.nlm.nih.gov/pubmed/34911999 http://dx.doi.org/10.1038/s41598-021-02985-7

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