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Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model

Age-related Macular Degeneration (AMD), a blinding eye disease, is characterized by pathological protein- and lipid-rich drusen deposits underneath the retinal pigment epithelium (RPE) and atrophy of the RPE monolayer in advanced disease stages - leading to photoreceptor cell death and vision loss....

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Detalles Bibliográficos
Autores principales:	Sharma, Ruchi, George, Aman, Nimmagadda, Malika, Ortolan, Davide, Karla, Barbosa-Sabanero, Qureshy, Zoya, Bose, Devika, Dejene, Roba, Liang, Genqing, Wan, Qin, Chang, Justin, Jha, Balendu Shekhar, Memon, Omar, Miyagishima, Kiyoharu Joshua, Rising, Aaron, Lal, Madhu, Hanson, Eric, King, Rebecca, Campos, Mercedes Maria, Ferrer, Marc, Amaral, Juan, McGaughey, David, Bharti, Kapil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674335/ https://www.ncbi.nlm.nih.gov/pubmed/34911940 http://dx.doi.org/10.1038/s41467-021-27488-x

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