Novel chemical inhibitor against SOD1 misfolding and aggregation protects neuron-loss and ameliorates disease symptoms in ALS mouse model

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective death of motor neurons. Mutations in Cu, Zn-superoxide dismutase (SOD1) causing the gain of its toxic property are the major culprit of familial ALS (fALS). The abnormal SOD1 aggregation in the motor...

Descripción completa

Detalles Bibliográficos
Autores principales: Woo, Tae-Gyun, Yoon, Min-Ho, Kang, So-mi, Park, Soyoung, Cho, Jung-Hyun, Hwang, Young Jun, Ahn, Jinsook, Jang, Hyewon, Shin, Yun-Jeong, Jung, Eui-Man, Ha, Nam-Chul, Kim, Bae-Hoon, Kwon, Yonghoon, Park, Bum-Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674338/
https://www.ncbi.nlm.nih.gov/pubmed/34912047
http://dx.doi.org/10.1038/s42003-021-02862-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674338/
https://www.ncbi.nlm.nih.gov/pubmed/34912047
http://dx.doi.org/10.1038/s42003-021-02862-z

Ejemplares similares