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Novel chemical inhibitor against SOD1 misfolding and aggregation protects neuron-loss and ameliorates disease symptoms in ALS mouse model

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective death of motor neurons. Mutations in Cu, Zn-superoxide dismutase (SOD1) causing the gain of its toxic property are the major culprit of familial ALS (fALS). The abnormal SOD1 aggregation in the motor...

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Detalles Bibliográficos
Autores principales:	Woo, Tae-Gyun, Yoon, Min-Ho, Kang, So-mi, Park, Soyoung, Cho, Jung-Hyun, Hwang, Young Jun, Ahn, Jinsook, Jang, Hyewon, Shin, Yun-Jeong, Jung, Eui-Man, Ha, Nam-Chul, Kim, Bae-Hoon, Kwon, Yonghoon, Park, Bum-Joon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674338/ https://www.ncbi.nlm.nih.gov/pubmed/34912047 http://dx.doi.org/10.1038/s42003-021-02862-z

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